Could one protein connect inflammation, ischemic injury and cancer?
This review explores #CyclophilinC (CypC) across coronary artery disease, brain ischemia, HCMV infection, glycemic control, liver fibrosis and #cancer.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

How does #ferroptosis drive cardiovascular, kidney and metabolic disorders?
This review highlights iron dysregulation, GPX4 inactivation and #LipidPeroxidation as key mechanisms and potential therapeutic targets in CKMS.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could #OGlycosylation reshape our understanding of #Type2Diabetes?
This review explores how O-GlcNAcylation and O-GalNAcylation regulate insulin secretion, metabolism, #InsulinResistance and diabetic complications.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Can NEIL #glycosylases protect #GenomeStability beyond base excision repair?
This review shows NEIL1–3 link BER to replication, transcription, mitochondria, immunity, and epigenetics, with dysregulation shaping #cancer and other diseases.
#GenesAndDiseases: doi.org/10.1016/j.ge...

How does the #nucleolus shape early development?
This review explores its remodeling in oocytes and embryos, highlighting roles in chromatin organization, #epigenetic inheritance, oocyte maturation and #EmbryonicDevelopment.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Controlling #ferroptosis may help limit #BrainInjury after #IntracerebralHemorrhage.
This study shows MEF2C suppresses oxidative stress and Fe²⁺ overload by activating FGF21, revealing a potential therapeutic pathway.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Targeting mitochondrial vulnerabilities could improve #TNBC treatment.
This review shows how altered #MitochondrialDynamics and metabolism drive tumor growth and #chemoresistance, highlighting new therapeutic strategies.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

How can chronic #HBV be controlled despite T-cell exhaustion?
CXCR5+CD8+ T cells retain #antiviral effector and B-cell helper functions, correlate with lower viral markers, and may offer a new therapeutic strategy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Decoding #PancreaticCancer requires uncovering #circRNA‑driven oncogenic programs.
NSUN2‑mediated circSMAD2 promotes tumor growth via ceRNA and m6A regulation, activating AKT/mTOR and emerging as a #biomarker and therapeutic target.
#GenesAndDiseases: doi.org/10.1016/j.ge...

Could a natural compound boost #BladderCancer treatment?
Echinocystic acid triggers #ferroptosis, suppresses AKT1/GSK3β/β-catenin signaling and enhances gemcitabine efficacy, offering a promising therapeutic strategy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

ZNF750 links lipid metabolism to ferroptosis in #ESCC.
By suppressing FADS1, it regulates #PUFA remodeling, while its loss increases #ferroptosis sensitivity through ACSL4, revealing therapeutic vulnerabilities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Why are #CardiovascularDiseases so difficult to control?
This review shows how histone #PTMs reshape gene expression and disease pathways, while highlighting their potential as therapeutic targets for emerging epigenetic treatments.
#GenesAndDiseases: doi.org/10.1016/j.ge...

Decoding bone loss requires uncovering estrogen‑linked cell death.
This study identifies an estrogen/SIRT5/FDX1 axis regulating cuproptosis, with SIRT5 rescuing #osteogenesis and offering therapeutic potential for #osteoporosis.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Could #cancer metabolism reveal a weakness in #ESCC?
This study identifies NT5E-driven pyrimidine metabolism as a therapeutic target and shows that icaritin suppresses ESCC by promoting NT5E degradation. #MetabolomicProfiling
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Harnessing transporter biology requires a unified view of #MFSD proteins.
This review consolidates their diverse roles in lipid transport, neurodevelopment, and cancer, positioning them as promising #TherapeuticTargets.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Decoding thyroid cancer progression requires understanding #m6A‑regulated drivers.
IGF2BP2 is upregulated in #PapillaryThyroidCarcinoma, promoting malignancy via SPRY1 and MAPK/MEK/ERK signaling, enhanced by TGF‑β/SMAD4.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Can #proteomics explain #SCLC treatment differences?
Profiling revealed distinct subtypes and immune landscapes linked to prognosis and immunotherapy response, offering a path to personalized therapy. #ImmuneMicroenvironment
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

How does #NLRP3 fuel #DiabeticHeart injury?
This review highlights its role in inflammation, oxidative stress, pyroptosis and fibrosis, while exploring NLRP3-targeted strategies to break the metabolism–inflammation cycle.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Preventing bone loss requires understanding #osteoclast formation.
This study shows #NuclearPoreComplexes reshape chromatin during osteoclastogenesis, revealing new therapeutic targets for bone diseases. #osteoporosis
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Improving cancer therapy may depend on exploiting #TumorSenescence.
This study introduces #MultiOmics SenScore to predict drug response and identify targets for more effective combination treatments. #senolytics
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...