Infection and hypoxic stress converge on the PHD1–TRIM21–CDC20 axis, promoting CDC20 degradation and securin and MCL1 accumulation to drive cancer cell #Aneuploidy and #Chemoresistance.
#STTT #OpenAccess: doi.org/10.1038/s413...

Targeting mitochondrial vulnerabilities could improve #TNBC treatment.
This review shows how altered #MitochondrialDynamics and metabolism drive tumor growth and #chemoresistance, highlighting new therapeutic strategies.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

CRIF1 Linked to Aggressive Endometrial Cancer and Reduced Response to Paclitaxel Treatment

🤖 IA: It's not clickbait ✅
👥 Users: It's not clickbait ✅

#endometrialcancer #chemoresistance #wntsignaling

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IRAK1 coordinates #Chemoresistance and #ImmuneEvasion in #NSCLC by regulating ABCB1/ABCC1 and LXRα–ABCA1 signaling, while its inhibition restores cisplatin sensitivity and enhances T-cell-mediated tumor killing.

#STTT #OpenAccess: doi.org/10.1038/s413...

TRAP1 drives #Cancer-associated adipocyte reprogramming and #Chemoresistance in #BreastCancer.

This study demonstrates that targeting mitochondrial TRAP1 suppresses pro-tumorigenic crosstalk and enhances #Chemotherapy efficacy.

#STTT #OpenAccess: doi.org/10.1038/s413...

Elevated #S100A8/A9 drives abnormal #proliferation, migration, #adhesion & #Chemoresistance in #DNMT3A mutant AML. Targeting this pathway could be a promising therapeutic strategy. #medsky

Read more: doi.org/10.1007/s115...

#currentmedicalscience #Oncology #CancerTherapeutics

#Infection and #Hypoxia converge on the PHD1–TRIM21–CDC20 axis to drive #Aneuploidy and #Chemoresistance, while CDC20 stabilization limits securin and MCL1 accumulation, reduces chromosomal imbalance, and restores #Chemosensitivity.

#STTT #OpenAccess: doi.org/10.1038/s413...