This study identifies SCFJFK as an E3 ligase that mediates #RUNX2 degradation, and a reciprocal RUNX2–JFK feedback loop linking #Proteostasis to #Osteogenesis and the pathogenesis of #CleidocranialDysplasia. @pku1898.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

Decoding bone loss requires uncovering estrogen‑linked cell death.
This study identifies an estrogen/SIRT5/FDX1 axis regulating cuproptosis, with SIRT5 rescuing #osteogenesis and offering therapeutic potential for #osteoporosis.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

More #mineral does not always make #bone stronger. In mice with high bone mass #osteogenesis imperfecta, abnormal collagen processing disrupted the bone matrix, producing thinner, poorly aligned mineral particles and bones that were highly mineralized but extremely brittle.👇
@brjournal.bsky.social