One RNA-modifying enzyme can influence #cancer across multiple tumors.
This review explores FTO’s context-dependent roles in cancer through #m6A demethylation, highlighting FTO as a promising therapeutic target. #Epitranscriptomic
#GenesAndDiseases: doi.org/10.1016/j.ge...

Could lactate-driven epigenetic changes shape cardiac recovery after #MyocardialInfarction?
This review explores histone lysine #lactylation and its interactions with other #PTMs in ischemia/reperfusion injury, revealing new targets.
#GenesAndDiseases: doi.org/10.1016/j.ge...

Could #miRNAs help overcome #BreastCancer treatment resistance?
This review examines how miRNAs and anti-miRs regulate apoptosis and responses to #radiotherapy and chemotherapy, revealing new therapeutic opportunities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Protecting the respiratory mucosa remains challenging.
This review explores #MucosalImmunity and next-generation #IntranasalVaccines, inhalable antibodies and broader antigen strategies to strengthen airway defense.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Tiny RNAs can have major consequences for cancer.
This review explores how #miRNAs regulate #TumorGrowth through JAK/STAT3, Wnt/β-catenin, PI3K/AKT, TGF-β and MAPK pathways, revealing therapeutic potential. #Biomarkers
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Uncovering #epilepsy genes could transform diagnosis and care.
This study identifies SBF1, CELSR2 and TENM1 as high-confidence candidate genes for #LennoxGastautSyndrome using individualized trio-based #exome analysis.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could altered fat metabolism be driving #vasculitis?
This study links enhanced fatty acid–acetyl-CoA flux and #ACSL4 activity in monocytes from pediatric #AAV patients to TGF-β and CD48 signaling, revealing new therapeutic targets.
#GenesAndDiseases: doi.org/10.1016/j.ge...

Could #HeartDisease also fuel #cancer?
This review explores #ReverseCardioOncology, showing how inflammation, oxidative stress and miRNAs may drive tumor progression and highlighting new therapeutic opportunities. #CVD
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

What makes CLDN7 lose its #TumorSuppressive power?
This study shows that APT1-driven #depalmitoylation destabilizes CLDN7, promoting #ccRCC invasion and revealing APT1 inhibition as a potential therapy. @pku1898.bsky.social
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

#Hexokinase2 does more than fuel cancer metabolism.
This review shows how it regulates #CellDeath, reshapes the #TumorMicroenvironment and promotes immune evasion, highlighting HK2-targeting therapies as promising strategies.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Metastatic #PancreaticCancer remains difficult to treat.
#AI-driven #MultiOmics analysis identifies PSMD10 as a #ferroptosis sensitizer, linking lipid metabolism to tumor vulnerability and revealing a potential therapeutic target.
#GenesAndDiseases: doi.org/10.1016/j.ge...

How is #PDL1 controlled beyond transcription?

This review explores phosphorylation, ubiquitination, glycosylation and acetylation, revealing how their crosstalk shapes immune escape and may guide #BreastCancer #immunotherapy.

#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Why do some #LungCancer patients fail to benefit from PD-1/PD-L1 #immunotherapy?
This study identifies ANP32A as a regulator of #PDL1, showing that its loss enhances EP300/CREBBP activity and may influence treatment response.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

SPOP may do more than control protein stability—it could organize #cancer-driving signals.
This review proposes SPOP as a molecular bridge that brings #OncogenicProteins together, forming pro-tumorigenic platforms.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could some microsatellite-stable #ColorectalCancers still respond to #immunotherapy?
This study identifies an “immune-enriched” subtype with greater immune infiltration, better survival and increased #antiPD1 sensitivity.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could reprogramming #Tregs limit #RadiationInducedLungInjury?
This study identifies the METTL3/miR-223-3p/Lif axis as a regulator of Treg differentiation and #fibrosis, revealing a potential therapeutic target.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Repairing the heart may require reprogramming immunity.
This study shows that mitochondria-rich #ExtracellularVesicles shift macrophages toward an anti-inflammatory state, improving recovery after #MyocardialInfarction. #Honokiol
#GenesAndDiseases: doi.org/10.1016/j.ge...

#PancreaticDuctalAdenocarcinoma thrives through both #tumor growth and immune suppression.
This study identifies the PKP3–P120 axis as a driver of IL-6/IL-8 signaling, tumor progression and M2 #macrophage polarization.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Genome fragility can shape disease risk.
This review highlights PARK2 as a fragile-site gene that links replication stress, #neurodegeneration, and #cancer, revealing its potential as both a biomarker and #PrecisionMedicine target.
#GenesAndDiseases: doi.org/10.1016/j.ge...

#COVID19 may leave a distinct brain signature.
This study links post-COVID brain changes to #olfactory-related regions and identifies S1 pyramidal #neuron activity as a key correlate of structural brain alterations.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...