"Oxidized PUFAs inside low-density lipoproteins (LDLs) trigger immune responses, prompt macrophage uptake, and promote arterial #plaque buildup."
#health #nutrition #diet #pufa #ldl #cvd

ZNF750 links lipid metabolism to ferroptosis in #ESCC.
By suppressing FADS1, it regulates #PUFA remodeling, while its loss increases #ferroptosis sensitivity through ACSL4, revealing therapeutic vulnerabilities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...