Wonderful to welcome our PhD alumni back after two decades. As faculty representative, I shared reflections on life and scholarship at Zhejiang University School of Medicine’s 20‑year reunion. #ZhejiangUniversity #bioiron #ferroptosis @elementjournal.bsky.social

New study reveals E3 ligase MARCH7 as a critical ferro-guardian, inhibiting ferroptosis by ubiquitylating NCOA4, regulating intracellular Fe²⁺ homeostasis. #Ferroptosis PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Metastatic #PancreaticCancer remains difficult to treat.
#AI-driven #MultiOmics analysis identifies PSMD10 as a #ferroptosis sensitizer, linking lipid metabolism to tumor vulnerability and revealing a potential therapeutic target.
#GenesAndDiseases: doi.org/10.1016/j.ge...

Targeting the UCHL5/ALK5 axis reveals a deubiquitination-driven mechanism that promotes autophagy-dependent #ferroptosis in chondrocytes and accelerates #osteoarthritis progression. Read more below!

PDF available: doi.org/10.1038/s420...

A phase I trial evaluates CNSI-Fe, a carbon #Nanoparticle–Fe(II) complex that delivers Fe iron directly into tumors to trigger #Cancer cell #Ferroptosis, showing a favorable safety profile and preliminary antitumor activity.

#STTT #OpenAccess: doi.org/10.1038/s413...

How do #Cuproptosis and #Ferroptosis intersect across disease?

This review connects metal metabolism, redox imbalance, organelle crosstalk, and regulatory networks with therapeutic strategies, #Biomarkers, and patient stratification.

#STTT #OpenAccess: doi.org/10.1038/s413...
#PrecisionOncology

Our Science Bulletin @sciencebulletin.bsky.social cover art and animation draw inspiration from Three Pools Mirroring the Moon. Either loss or excess of SLC7A11 disrupts amino acid homeostasis and induces ferroptosis, promoting MASLD. PMID: 39366830 #Ferroptosis #CellDeath #MASLD #MAFLD

Happy Mid-Autumn Festival. Under the full moon, we pursue truth and harvest discovery. May wisdom and abundance abide with you.#Ironmetabolism #Ferroptosis @nature.com @cellpress.bsky.social @science.org @elementjournal.bsky.social @brentstockwell.bsky.social @linkermannlab.bsky.social

#InflammatoryBowelDisease (IBD) involves more than persistent inflammation.
This review highlights how #ferroptosis, iron overload and microbiota–immune interactions drive barrier damage and reveal new therapeutic targets.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

How does #ferroptosis drive cardiovascular, kidney and metabolic disorders?
This review highlights iron dysregulation, GPX4 inactivation and #LipidPeroxidation as key mechanisms and potential therapeutic targets in CKMS.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Element Scientific Exploration Webinar

📅 Oct 21, 2026 | 13:30 (UTC+8)

📍 Zhejiang University + Online

Join Prof. Tom Vanden Berghe for “To Die or Not to Die: Targeting Ferroptosis in Disease”

Scan the Poster to Register Free

#Ferroptosis #CellDeath @fudiwang.bsky.social

Controlling #ferroptosis may help limit #BrainInjury after #IntracerebralHemorrhage.
This study shows MEF2C suppresses oxidative stress and Fe²⁺ overload by activating FGF21, revealing a potential therapeutic pathway.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Happy #Mitochondria Monday ;) Kick off your week with Christian Frezza's @biomednews.bsky.social curation on #mitochondriametabolism #mitocancer and #ferroptosis advances:

biomed.news/bims-camemi/...

#mitoscientists #aging

Our new review has just been published in Nature Reviews Nephrology @natrevneph.nature.com . This review centers on ferroptosis‑driven renal injury across multiple kidney diseases.🔗 Free to read full text: rdcu.be/hu1mDMxZvvXa
#ferroptosis #KidneyDiseases #nature #nutrition

Thrilled our new review is published in @natrevimmunol.nature.com We dissect ferroptosis in T‑cells and summarize ferroptosis across immune cells. Open for collaborations. 🔗 Free to read full text: t.co/QyKcAh8jBc
#ferroptosis #immunology #biometal #bioiron

Thrilled our paper is published in @cellpress.bsky.social
MARCH7, an E3 ubiquitin ligase, acts as a ferro‑guardian against ferroptosis. Open for collaborations😘 Full text: doi.org/10.1016/j.ce...
#ferroptosis #ironmetabolism #ubiquitination

Thrilled our new paper is published in @nature.com
Mitochondrial fission factor MFF senses and governs ferroptosis. Open for future collaborations.🔗 go.nature.com/46thBrP
Free to read full text: t.co/3PDmnIHr9V
#ferroptosis #mitochondria #ironmetabolism

Could a natural compound boost #BladderCancer treatment?
Echinocystic acid triggers #ferroptosis, suppresses AKT1/GSK3β/β-catenin signaling and enhances gemcitabine efficacy, offering a promising therapeutic strategy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

ZNF750 links lipid metabolism to ferroptosis in #ESCC.
By suppressing FADS1, it regulates #PUFA remodeling, while its loss increases #ferroptosis sensitivity through ACSL4, revealing therapeutic vulnerabilities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Postdoc Portrait: #SarahGregor Explores #Ferroptosis in Blood Disorders

This postdoctoral researcher investigates the role of ferroptosis in blood disorders to uncover precise cellular targets for therapy
#Biochemistry #Science