@sigtrans-sttt.bsky.social#Mucosaltissues serve as primary pathogen entry points requiring specialized defenses.
A review of the immune mechanisms and #Vaccine delivery platforms that elicit local & systemic responses, as well as the challenges for next-gen #MucosalVaccines.
@sigtrans-sttt.bsky.social#TumorHeterogeneity challenges antigen-specific #Vaccination.
This review explores how in situ #CancerVaccines combine immunogenic cell death, advanced delivery, microenvironment modulation, and checkpoint blockade to broaden antitumor immunity.
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.socialHow can next-generation personalized #CancerVaccines overcome #Immunosuppressive microenvironments?
This review evaluates mRNA, DNA, and #Nanovaccine platforms combined with checkpoint inhibitors for durable immunity.
@sigtrans-sttt.bsky.socialThis review links genomic and #Epigenetic changes, metabolic adaptation, immune escape, and therapy-driven selection to emerging evolution-guided strategies for #PrecisionOncology. @fudan-university.bsky.social
@sigtrans-sttt.bsky.socialENO1 connects #Glycolysis with #GastricCancer stemness by regulating ATP pools and lactate homeostasis, which coordinate AMPK/mTOR and PI3K/AKT signaling to promote EMT, self-renewal, migration, and invasion.
@sigtrans-sttt.bsky.socialCan light power stressed #Mitochondria? Engineered mt-EcGAPR uses ambient light to enhance ATP production and reduce ROS, suppressing ER stress–ATF6–GSDMD-mediated #Pyroptosis and protecting retinal ganglion cells.
#STTT #OpenAccess: doi.org/10.1038/s413...
#RetinalResearch #Neuroscience
@sigtrans-sttt.bsky.social#Piezo1 links mechanical cues to bone marrow stem-cell fate. Its activation suppresses the Ccl2–CCR2–NF-κB–Lcn2 inflammatory loop, limiting adipogenesis while promoting osteoblast differentiation and #boneformation. #Osteoporosis
@sigtrans-sttt.bsky.social#ArterialStiffness links vascular aging with #cardiovascular and end-organ damage. This review explores its structural and functional mechanisms, clinical measurement, and emerging strategies for personalized prevention and therapy.
#STTT #OpenAccess: doi.org/10.1038/s413...
#PrecisionMedicine
@sigtrans-sttt.bsky.socialNew first-line strategies are needed for metastatic #ColorectalCancer. The APICAL-CRC phase II trial finds promising #antitumor activity and manageable safety with sintilimab plus anlotinib in treatment-naïve patients.
#STTT #OpenAccess: doi.org/10.1038/s413...
#MetastaticCRC #Immunotherapy
@sigtrans-sttt.bsky.socialGlutamine #metabolism has diverse roles across health and disease. This review explores its links to #Cancer, #Neurodegeneration, metabolic and #cardiovasculardisorders, microbiome interactions, and emerging therapeutic strategies.
@sigtrans-sttt.bsky.socialCan microbial exposure strengthen pulmonary host defense?
#Pseudomonas aeruginosa LPS primes lung-resident NK cells through C3aR1, enhancing IFN-γ production and LFA-1-dependent adhesion to protect against #BacterialPneumonia.
@sigtrans-sttt.bsky.socialCan routine histology reveal molecular subtypes of #PancreaticCancer?
A graph-constrained model links H&E morphology with gene co-expression structure to predict basal-like and classical PDAC subtypes.
#STTT #OpenAccess: doi.org/10.1038/s413...
#GeneExpression #CancerGenomics
@sigtrans-sttt.bsky.socialAortic valve calcification remains an unmet therapeutic challenge. Activating histone #acetylation with SPV106 restores Notch1 expression and 3chromatin regulation, reversing the senescent–calcific phenotype of valve cells. @alfaisaluniversity
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.socialTargeting LRRC15+ tumor tissue may help dismantle mechanisms of #Immunotherapy resistance. DUNP19 enables radio-imaging and #Radiotherapy while suppressing pro-tumorigenic programs and potentiating checkpoint blockade. @uofcalifornia.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.socialHow do gasdermin proteins execute inflammatory #CellDeath and drive disease pathology?
Insights into their activation, membrane pore formation, cell-death crosstalk, and context-dependent roles in #Inflammation, infection, and #Cancer.
@sigtrans-sttt.bsky.socialWhat drives #VascularCalcification beyond mineral deposition?
This review explores VSMC remodeling, #EndMT, cellular stress, and RUNX2-centered signaling crosstalk while assessing emerging therapeutic strategies.
@sigtrans-sttt.bsky.socialCan hyperactive #DNArepair be targeted in #Neuroendocrine #CervicalCarcinoma?
#Multiomics reveals HRR activation and a CAF–IL6–E2F1–BLM axis that limits #PARP inhibitor sensitivity, supporting dual PARP–BLM inhibition.
@sigtrans-sttt.bsky.socialLoss of βPIX in alveolar type 2 cells impairs stemness through reduced Wnt/β-catenin signaling, promoting transitional senescent progenitors and #Myofibroblast activation that drive spontaneous #PulmonaryFibrosis.
@sigtrans-sttt.bsky.socialA safer VSV-based intranasal #H5N1 #Vaccine elicits robust and durable humoral and mucosal immunity, with the optimized vector protecting against lethal viral challenge and supporting its potential for #AvianInfluenza prevention.
@sigtrans-sttt.bsky.socialThe melanoma-enriched noncanonical antigen EVA003 is endogenously presented on HLA-A*03:01 and recognized by a naturally occurring T cell receptor that, when transferred into T cells, enables antigen-dependent #Melanoma cell killing.
