@currentmedscience.bsky.social#Hypoxia makes liver cancer harder to treat.
This study shows that 3-BrPA enhances arterial #embolization, suppressing tumor growth and promoting necrosis, offering a strategy to overcome hypoxic resistance.
#currentmedicalscience: doi.org/10.1007/s115...
@paulmac.bsky.social
@narjournal.bsky.social15. Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment - Espín et al. doi.org/10.1093/narc... Links #hypoxia/HIF1α and #MYC to #PARP1/POLQ expression and alternative end joining, with combination-treatment effects in cancer cells. 16/18
@abioticstress.bsky.socialChemical #priming of #hypoxia responses via PLANT #CYSTEINE OXIDASE inhibition improves #flooding tolerance
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
@physrep.bsky.socialStudy of #hemoglobin mass and #plasma volume regulation in adults from six Andean regions at different altitudes reports #hemoconcentration and #erythropoiesis contribute equally to increased [Hb] at moderate #altitude.
doi.org/10.14814/phy...
#Hypoxia
@paulmac.bsky.social
@paulmac.bsky.social@paulmac.bsky.social@paulmac.bsky.social@paulmac.bsky.social
@haoyin.bsky.socialCarbonic anhydrase 9, an intracellular pH regulator, is widely used to mark #Hypoxia in tumors (+some tissues)
Here's new evidence for CA9 (+CA12) in human pulmonary arterial #SmoothMuscleCell & 🐭#PulmonaryHypertension (S4, CA9/CA12 dual inhibitor) 😎
@mdpipharma.bsky.social🎯 Non-toxic #multidrug combos for RCC—rationally designed, hypoxia-enhanced. ODCs show up to 77% efficacy in 2D & 62% in 3D spheroids. Durable responses, no toxicity in organ models.
📌 doi.org/10.3390/phar...
#RCC #DrugCombinations #Hypoxia #CancerTherapy
@msmjetten.bsky.socialArtificial downwelling for mitigating marine #hypoxia: a review of biogeochemical responses, ecological effects, and adaptive optimization strategies link.springer.com/article/10.1...
@lucidscientific.bsky.socialHow do cells rewire fat metabolism when oxygen runs low? At #HypoxEU, @LozaValdes (@UniHeidelberg) showed losing the E3 ligase RNF145 helps cells survive hypoxia by storing fatty acids as triacylglycerol instead of toxic lipids. Great poster, Angel! #Hypoxia #LipidMetabolism
@paulmac.bsky.social@abioticstress.bsky.socialBeyond #hypoxia: Context-dependent #transcriptional reprogramming by #ERFVIIs
onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @jipb.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social @plantresearch.bsky.social
@itmat.bsky.social#TherapeuticPotential of combining #IRE1α and #KRAS inhibition in #PancreaticDuctalAdenocarcinoma doi.org/10.1073/pnas... #PDAC #Hypoxia #Oncology #LiverCancer #SolidTumor #TranslationalScience
@sigtrans-sttt.bsky.social#Hypoxia enhances EnAd oncolytic activity via HIF-2α/HIF-1β-mediated activation of an E1A promoter HRE, revealing how tumor microenvironments drive viral replication and inform #Adenovirus-based therapies for #SolidTumors. @ox.ac.uk
@apspublications.bsky.socialFunction 🔙 Throw Back Thursday: Signal Transduction Pathway Mediating #Carotid Body Dependent #Sympathetic Activation and #Hypertension by Chronic Intermittent #Hypoxia. https://ow.ly/wo5350ZPgsW
@abioticstress.bsky.socialBeyond #hypoxia: Context-dependent #transcriptional reprogramming by #ERFVIIs
onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience #SciComm @jipb.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @isplore.bsky.social @pgrp2026.bsky.social @plant-sci.bsky.social @sciplant.bsky.social