While PJ.2.1 does not demonstrate an immediate, definitive transmission advantage via #immuneevasion, its evolutionary strategy poses a significant #publichealth risk
@castltrastondrs.medsky.network
@castltrastondrs.medsky.networkWhile PJ.2.1 does not demonstrate an immediate, definitive transmission advantage via #immuneevasion, its evolutionary strategy poses a significant #publichealth risk
@sigtrans-sttt.bsky.socialHow durable is immunity after an XBB.1.5 booster? This longitudinal study tracks neutralizing antibody responses after trivalent XBB.1.5 #Vaccination, examining their magnitude, breadth, durability, and evolution against #SARSCoV2 variants.
#STTT #OpenAccess: doi.org/10.1038/s413...
#ImmuneEvasion
@sigtrans-sttt.bsky.socialIRAK1 coordinates #Chemoresistance and #ImmuneEvasion in #NSCLC by regulating ABCB1/ABCC1 and LXRα–ABCA1 signaling, while its inhibition restores cisplatin sensitivity and enhances T-cell-mediated tumor killing.
@sigtrans-sttt.bsky.socialLoss of KLF4 can facilitate #ImmuneEvasion in #EsophagealCancer.
This study links KLF4 downregulation to impaired MHC class I antigen presentation and shows that restoring KLF4 can enhance response to PD-1 blockade.
