@sigtrans-sttt.bsky.socialInfection and hypoxic stress converge on the PHD1–TRIM21–CDC20 axis, promoting CDC20 degradation and securin and MCL1 accumulation to drive cancer cell #Aneuploidy and #Chemoresistance.
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.social#Infection and #Hypoxia converge on the PHD1–TRIM21–CDC20 axis to drive #Aneuploidy and #Chemoresistance, while CDC20 stabilization limits securin and MCL1 accumulation, reduces chromosomal imbalance, and restores #Chemosensitivity.
