Preventing bone loss requires understanding #osteoclast formation.
This study shows #NuclearPoreComplexes reshape chromatin during osteoclastogenesis, revealing new therapeutic targets for bone diseases. #osteoporosis
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Improving cancer therapy may depend on exploiting #TumorSenescence.
This study introduces #MultiOmics SenScore to predict drug response and identify targets for more effective combination treatments. #senolytics
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

What if stronger #immunotherapy begins with building immune hubs inside tumors?
This study shows NT-I7 induces TLS-like structures, boosting #antitumor immunity and supporting better responses to PD-1 blockade.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

See how better variant classification can improve patient care.
This study introduces a more accurate way to distinguish #GABRA1 mutations, supporting better diagnosis and treatment of #NeurologicalDisorders. #epilepsy
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Treating #LiverDiseases remains challenging because immune signaling can both protect and damage tissue.
This review highlights the #STINGpathway and #nanodrug delivery as promising tools for targeted liver therapies.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Treating #osteoporosis starts with slowing skeletal #aging.
This study identifies FRMD6 as a driver of bone marrow cell senescence and shows crocin I can counter this process, offering a promising therapeutic target.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Beating #ColorectalCancer requires smarter therapeutic targets.
This study identifies KAT2A as a driver of tumor growth and immune evasion, highlighting its potential as a biomarker and precision target. @fudan-university.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...

Promising therapies need stronger clinical evidence.
This review explains how autologous ozonized blood transfusion reduces #OxidativeStress and #inflammation while highlighting barriers to wider adoption. #NRF2 #NFκB
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

#GutMicrobiota, metabolites, and vitamin levels shape #ThyroidCancer progression.
Stage‑specific microbial shifts, metabolic reprogramming, and reduced vitamins C/D highlight stakes for early detection and biomarker discovery.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Learn how a #lncRNA fuels #ColorectalCancer.
This study identifies AC004854.2 as a driver of c-MYC transcription through the SOX4/AC004854.2/PUF60 axis, highlighting a promising #biomarker and therapeutic target beyond WNT/β-catenin.
#GenesAndDiseases: doi.org/10.1016/j.ge...

What if #aging cells keep inflammation alive by leaking their own DNA?
This review shows how #MitochondrialDNA leakage fuels cellular senescence and highlights blocking its release as a promising anti-aging strategy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Learn how DYRK kinases shape cancer therapy.
This review shows how DYRK proteins regulate #DNADamageResponse and highlights DYRK inhibitors as promising #PrecisionOncology strategies to exploit cancer-specific DNA repair vulnerabilities.
#GenesAndDiseases: doi.org/10.1016/j.ge...

Precision cancer therapy starts with RNA regulation.
This review highlights how the #N6methyladenosine (m6A) demethylase FTO drives #GastrointestinalCancer and why FTO inhibitors are emerging as promising therapeutic targets.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Learn what drives #IntervertebralDiscDegeneration.
This study identifies SPP1⁺ macrophages as key mediators of matrix damage and shows that SPP1-silenced #exosomes protect intervertebral discs, offering a promising therapeutic strategy.
#GenesAndDiseases: doi.org/10.1016/j.ge...

How do uniform tissues become complex?
This review uses #SkinAppendages to show how #SymmetryBreaking—via morphogens, mechanics, and microenvironmental cues—drives patterning, stem cell regulation, and disease remodeling.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Can force-sensing ion channels improve #orthodontics?
This review shows how #PiezoChannels regulate tooth movement, pain, and dentofacial development, making them promising therapeutic targets. #craniofacial
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Is #ImmuneAging undermining #GastrointestinalCancer therapy?
This review links T cell exhaustion, SASP, and microbiota-driven inflammation to resistance, spotlighting senolytics and microbiota-targeted strategies.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Why is #EarlyOnsetColorectalCancer more aggressive?
This study links the PPARγ–EMP1 axis to lipid-driven immune suppression, revealing a target that restores CD8⁺ T-cell function and improves anti-PD-1 therapy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Better #CancerImmunotherapy requires tackling hidden immune barriers.
This review highlights how dysfunctional #Bcells suppress anti-tumor immunity and outlines strategies to reprogram the #TumorMicroenvironment.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Learn how betaine protects bone.
This study shows betaine blocks #ferroptosis, restores osteogenesis via the ABCG1–HMOX1 axis, and emerges as a promising therapy for #RenalOsteodystrophy. #ChronicKidneyDisease
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...