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@gpbees.bsky.socialOct 9, 2026, 2:55 AM

5/5: Beyond immune cells
Attenuated CXCL12-CXCR4 and ICAM1-SPN signaling, together with a marrow-specific tumor metaprogram involving IGFBP3/NAMPT, points to disruption of hematopoietic niche support.
#CancerResearch #TumorMicroenvironment

@genesndiseases.bsky.socialOct 8, 2026, 12:01 PM

#Hexokinase2 does more than fuel cancer metabolism.
This review shows how it regulates #CellDeath, reshapes the #TumorMicroenvironment and promotes immune evasion, highlighting HK2-targeting therapies as promising strategies.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

@thebabaklab.bsky.socialOct 7, 2026, 7:51 PM

In a new Cell review, Douglas Hanahan revisits one of the most influential frameworks in cancer biology.

Link in the comments 👇

#HallmarksOfCancer #CancerResearch #Oncology #TumorMicroenvironment #CancerBiology #PrecisionMedicine

@plosbiology.orgOct 7, 2026, 6:09 AM

#TrendingNow | Within the #TumorMicroenvironment, cells engage in dynamic metabolic competition. This Essay discusses metabolic crosstalk between #cancer cells and #TCells, highlighting metabolic targeting as a promising strategy to reprogram anti-tumor immune responses 🧪 #ICYMI plos.io/3U6RWir

@alicefrolov.bsky.socialOct 2, 2026, 5:01 PM

The Vascular Normalization Window in Anti-VEGF Therapy

I am sharing a figure intended to communicate the transient nature of vascular normalization.

#TumorAngiogenesis #VascularNormalization #AntiVEGF #TumorMicroenvironment #Pericytes #TumorVasculature #AntiangiogenicTherapy #CancerBiology

The Vascular Normalization Window in Anti-VEGF Therapy I am sharing a figure intended to communicate the transient nature of vascular normalization during anti-angiogenic treatment, a concept that continues to shape dosing and combination strategy discussions. I want to emphasize at the outset that the underlying data are simulated; the curves are constructed to reproduce trends reported across the preclinical and clinical literature rather than to present novel measurements. The plot is a temporal contour band plot rendering two opposing envelopes against time following VEGF pathway blockade. The first envelope tracks pericyte coverage of the tumor microvasculature, expressed as fractional NG2/PDGFRβ-positive perivascular investment, which rises as VEGF withdrawal reduces the destabilizing pressure on nascent endothelium. The second envelope tracks microvessel density, which declines as immature, poorly perfused vessels regress. The shaded intersection identifies the normalization window, the interval during which pericyte recruitment and basement membrane maturation restore a more physiologically competent vascular phenotype before pruning progresses toward frank hypovascularity. Within this window the figure annotates the functional correlates that motivate combination scheduling: reduced interstitial fluid pressure, attenuated hypoxia, improved oxygen and drug delivery, and partial restoration of endothelial barrier integrity. The band widths encode illustrative uncertainty, reflecting the heterogeneity in window timing and duration observed across tumor models and dosing regimens. The mechanistic argument the figure supports is that therapeutic benefit from normalization is inherently self-limiting. Sustained or excessive VEGF inhibition drives the system past the window into a hypoxic, treatment-resistant state, whereas appropriately timed cytotoxic or immunotherapeutic delivery may exploit the transient perfusion gain.
@sigtrans-sttt.bsky.socialOct 1, 2026, 7:42 AM

A multitarget strategy may help address #TNBC heterogeneity.

Opti-hTIF1γ suppresses β-catenin, TGFβ and STAT3 signaling while downregulating CD47 and CXCL5, enhancing #macrophage phagocytosis and #antitumoractivity.
#TumorMicroenvironment #CancerBiology
#STTT #OpenAccess: doi.org/10.1038/s413...

Transcriptional intermediary factor 1 gamma-based multitarget gene therapeutic strategy for triple-negative breast cancer
@svanuytven.eurosky.socialSep 30, 2026, 8:49 AM

Weekly reads 21/09/26:
How tumors exploit cell states and how we're learning to engineer our own

behindthebioinformatics.substack.com/p/weekly-rea...

#CancerResearch #SingleCell #TumorMicroenvironment #SyntheticBiology

@sigtrans-sttt.bsky.socialSep 29, 2026, 9:15 AM

TKTL1-driven #Glycolysis increases lactate and promotes #Immunosuppressive dendritic-cell signaling in #HCC. Targeting the TKTL1–HIF-1α–HK2 axis and lactate reprograms the #TumorMicroenvironment to enhance PD-1 blockade.

#STTT #OpenAccess: doi.org/10.1038/s413...

Transketolase-like 1 potentiates PD-1 blockade in hepatocellular carcinoma by glycolysis to prime dendritic cell lactylation
@genesndiseases.bsky.socialSep 27, 2026, 1:30 AM

#BrainMetastases are shaped by complex #TumorMicroenvironment interactions.
This study identifies the MIF–CD74 axis as a key tumor–myeloid hub and links pDC signatures to shorter survival, highlighting a potential target.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

@isev.orgSep 25, 2026, 12:41 PM

📘Read in #JEV📘 Small Extracellular Vesicle-Derived Nidogen 1 Promotes HCC Carcinogenesis via Transglutaminase 3-Mediated YAP/TAZ Signalling #extracellularvesicles #hepatocellularcarcinoma #nidogen1 #tumormicroenvironment isevjournals.onlinelibrary.wiley.com/doi/epdf/10....

@ontarget-podcast.bsky.socialSep 23, 2026, 7:26 PM

Mirna Jarosz, CEO of #LiquidCellDx, explains how her company's #liquidbiopsy captures information about the #tumormicroenvironment, providing critical treatment guidance.

🎧 Listen now → www.ontargetpodcast.com

#OnTarget #PrecisionMedicine #Oncology #Immunotherapy #CancerDiagnostics #AI

@cancers-mdpi.bsky.socialSep 23, 2026, 8:38 AM

📣Check out some highly cited #SpecialIssues in 2025 related to our section "Tumor Microenvironment"

Explore here🔎 www.mdpi.com/about/announ...

#TumorMicroenvironment #metastasis #angiogenesis #IntercellularCommunication @mdpiopenaccess.bsky.social

@cancers-mdpi.bsky.socialSep 17, 2026, 10:16 AM

🧬Spatial #Transcriptomics in #LungCancer and Pulmonary Diseases: A Comprehensive Review

🧑‍🔬by Da Hyun Kang, Yoonjoo Kim et al. from Chungnam National University

📊Cited 19 times!

Read it here🔗 www.mdpi.com/2072-6694/17...

#SpatialTranscriptomics #PulmonaryDisease #TumorMicroenvironment

Figure 4. Spatial transcriptomic signatures across pulmonary diseases: cellular niches and molecular pathways.
@biomedicines.bsky.socialSep 16, 2026, 7:19 AM

⚕️ The tumor microenvironment of pancreatic cancer remains a major obstacle. This review examines strategies to enhance immune activation and improve the effectiveness of immunotherapy combinations. #PancreaticCancer #TumorMicroenvironment
www.mdpi.com/2227-9059/12...

@alicefrolov.bsky.socialSep 14, 2026, 5:03 PM

Sharing a visualization from our ongoing modeling work on intratumoral oxygen dynamics and the HIF-1α-driven transcriptional response.

#TumorHypoxia #HIF1alpha #TumorMicroenvironment #Angiogenesis #OxygenSensing #VEGF #ComputationalOncology #CancerMetabolism

Sharing a visualization from our ongoing modeling work on intratumoral oxygen dynamics and the HIF-1α-driven transcriptional response. Figure: "Oxygen tension collapse drives coordinated hypoxia-angiogenesis program across the tumor radius" Subtitle: "Simulated intratumoral pO₂ gradient from vessel wall to necrotic core with HIF-target activation" The figure uses a horizon-style stacked area representation (layered oxygen-gradient contour strip) to render pO₂ as a function of radial distance from the perfused vessel wall toward the necrotic core. Each contour band encodes a discrete oxygen tension interval, with marker overlays indicating the activation thresholds of canonical HIF-1α target loci. I want to emphasize that the underlying data are simulated; the parameterization reflects diffusion-limited oxygen distributions consistent with published Krogh-cylinder estimates and the well-characterized ~100–200 µm diffusion limit. The central observation is the coordinated character of the transcriptional program along the radial axis. Proximal to the vessel wall, pO₂ remains above the threshold for prolyl hydroxylase domain (PHD/EGLN) activity, sustaining VHL-mediated HIF-1α degradation. As oxygen tension declines toward the intermediate perinecrotic zone, PHD activity becomes substrate-limited, HIF-1α escapes hydroxylation and proteasomal turnover, and it accumulates to drive HRE-dependent transcription. The marker overlays illustrate the staggered engagement of glycolytic effectors (SLC2A1, LDHA), pH-regulatory targets (CA9), and pro-angiogenic signaling (VEGFA) as the gradient steepens. The horizon-strip format was chosen deliberately to compress the steep radial pO₂ decay into a legible vertical encoding while preserving the coincidence between tension thresholds and target activation.
@sigtrans-sttt.bsky.socialSep 11, 2026, 12:30 PM

Myeloid-derived suppressor cells promote immune escape and tumor progression through #MetabolicReprogramming, altered differentiation and interactions within the #TumorMicroenvironment, highlighting their theranostic potential.

#STTT #OpenAccess: doi.org/10.1038/s413...

Myeloid-derived suppressor cells in cancer: biology, regulatory networks and theranostic prospects
@genesndiseases.bsky.socialSep 11, 2026, 2:00 AM

Better #CancerImmunotherapy requires tackling hidden immune barriers.
This review highlights how dysfunctional #Bcells suppress anti-tumor immunity and outlines strategies to reprogram the #TumorMicroenvironment.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

@genesndiseases.bsky.socialSep 9, 2026, 12:30 PM

Precision medicine is transforming #cholangiocarcinoma care.
This review highlights advances in targeted therapies and #immunotherapy while addressing challenges such as drug resistance and biomarker discovery. #TumorMicroenvironment
#GenesAndDiseases: doi.org/10.1016/j.ge...