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@sigtrans-sttt.bsky.socialOct 8, 2026, 6:15 AM

New first-line strategies are needed for metastatic #ColorectalCancer. The APICAL-CRC phase II trial finds promising #antitumor activity and manageable safety with sintilimab plus anlotinib in treatment-naïve patients.

#STTT #OpenAccess: doi.org/10.1038/s413...
#MetastaticCRC #Immunotherapy

Anlotinib plus sintilimab as first-line treatment for patients with advanced colorectal cancer (APICAL-CRC): an open-label, single-arm, phase II trial
@plosbiology.orgSep 17, 2026, 12:55 PM

Acute #infections have been linked to #cancer progression, but they can also elicit #AntiTumor immune responses. This study explores gaps in understanding how infections differentially skew #immune programs to promote or restrain cancer progression @plosbiology.org 🧪 buff.ly/QfAWXBo

Upper left – healthy lung with a rare dormant cancer cell (green). Lower right – lung after infection with respiratory virus, showing expansion of dormant cancer cells (green cells; pink nucleus indicates active cell cycling). Image credit: Michael DeGregori.
@plosbiology.orgSep 16, 2026, 4:30 PM

Acute #infections have been recently linked to #cancer progression, but they can also elicit #AntiTumor immune responses. This study explores gaps in understanding how infections differentially skew #immune programs to promote or restrain cancer progression @plosbiology.org 🧪 buff.ly/QfAWXBo

Upper left – healthy lung with a rare dormant cancer cell (green). Lower right – lung after infection with respiratory virus, showing expansion of dormant cancer cells (green cells; pink nucleus indicates active cell cycling). Image credit: Michael DeGregori.
@plosbiology.orgSep 16, 2026, 9:04 AM

Acute #infections have been recently linked to #cancer progression, but they can also elicit #AntiTumor immune responses. This article explores our gaps in understanding how infections differentially skew #immune programs to promote or restrain cancer progression @plosbiology.org 🧪 plos.io/3UYYcMS

Upper left – healthy lung with a rare dormant cancer cell (green). Lower right – lung after infection with respiratory virus, showing expansion of dormant cancer cells (green cells; pink nucleus indicates active cell cycling). Image credit: Michael DeGregori.
@genesndiseases.bsky.socialSep 16, 2026, 2:00 AM

What if stronger #immunotherapy begins with building immune hubs inside tumors?
This study shows NT-I7 induces TLS-like structures, boosting #antitumor immunity and supporting better responses to PD-1 blockade.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...