Why do so many #cancers eventually stop responding to treatment?
This review shows how protein modifications rewire tumour defences and highlights emerging strategies, from #PROTACs to #AI-guided approaches, to overcome resistance.
#GenesAndDiseases: doi.org/10.1016/j.ge...

What controls the balance between #cartilage and #BoneFormation?
ST3GAL1-associated α-2,3 sialylation regulates chondrocyte and #osteoblast differentiation, with its loss impairing growth plate maturation & reducing bone mass.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

#CRISPRCas is reshaping the future of #PrecisionMedicine.
This review explores its mechanisms, delivery and medical applications, while highlighting challenges in efficiency, transcriptional control and biosafety.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could #tumor metabolism drive T-cell exhaustion?
CD147 enhances tryptophan uptake and kynurenine production in #NSCLC, promoting CD8+ T-cell exhaustion, while CD147-targeted CAR-T plus anti-PD-1 shows therapeutic potential.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Targeting RRM2 could tackle both #HCC and #HBV.
This study identifies HP28 and HP39 as RRM2 inhibitors that deplete dNTPs, suppress #tumor growth and HBV replication, and retain activity against sorafenib-resistant HCC.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

#Phosphorylation may hold a key to slowing #osteoarthritis.
This review shows how MAPK, PI3K/AKT and NF-κB phosphorylation regulate chondrocyte metabolism, apoptosis and inflammation, revealing new therapeutic opportunities.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Could a frequently mutated gene reveal new vulnerabilities in #HepatocellularCarcinoma (HCC)?
This study identifies PTPRG as a #TumorSuppressor whose loss activates FAK/PI3K/AKT signaling, promoting HCC progression.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

#BrainMetastases are shaped by complex #TumorMicroenvironment interactions.
This study identifies the MIF–CD74 axis as a key tumor–myeloid hub and links pDC signatures to shorter survival, highlighting a potential target.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

What drives chondrocyte hypertrophy in #osteoarthritis?
This study identifies #POSTN as a regulator of #RUNX2-driven hypertrophy, with its suppression reducing cartilage damage, synovial inflammation and OA progression.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Targeting #IRF4 could open a new path for #MultipleMyeloma therapy.
G1126 suppresses myeloma growth, reduces lenalidomide-resistant cells and enhances #chemotherapy response while sparing normal stem cells. @ECNUER
#GenesAndDiseases: doi.org/10.1016/j.ge...

Could #platelets provide a window into #ParkinsonsDisease?
This study identifies shared chromatin pathways and highlights platelet-derived CRLF3 and LRRC37A2 as promising diagnostic #biomarkers for PD. @pku1898.bsky.social
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

A new #antiviral mechanism may help tackle #HepatitisBvirus persistence.
FAM151A suppresses HBV replication by inhibiting cccDNA transcription without reducing its abundance, revealing a host defense mechanism against HBV infection.
#GenesAndDiseases: doi.org/10.1016/j.ge...

A new strategy could improve #IntrahepaticCholangiocarcinoma (ICC) therapy.
This study shows PD-161570 suppresses YY1-driven #AURKA transcription and synergizes with MLN8237, inhibiting ICC progression in vitro and in vivo.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

What keeps #βCatenin active in cancer?
This study identifies #Doublecortin as a novel regulator that stabilizes β-Catenin, enhances its transcriptional activity and promotes #HCC progression. @emorydeptofmed.bsky.social
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Mitochondrial redox balance could reveal new cancer clues.
This pan-cancer study links SLC25A39 to tumor progression, immune checkpoints and #immunotherapy response, highlighting its #biomarker potential. #GastricCancer
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Can #AI move beyond prediction to explain disease?
This review outlines how trustworthy AI can link #MultiOmics, imaging, pathology and real-world data to biological mechanisms, robust validation and #PrecisionMedicine.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

#InflammatoryBowelDisease (IBD) involves more than persistent inflammation.
This review highlights how #ferroptosis, iron overload and microbiota–immune interactions drive barrier damage and reveal new therapeutic targets.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Which genes drive early #PancreaticCancer metastasis?
Integrating transcriptomic, single-cell and #MachineLearning data identified ITGA3 as a key pro-metastatic gene and potential therapeutic target in PDAC.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Why does #ColorectalCancer keep resisting #5Fluorouracil chemotherapy?
This study shows that arachidonic acid–driven lipophagy sustains resistant cells, suggesting a strategy to restore chemotherapy sensitivity. #DrugResistance
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Could RNF128 be the missing link in #HFpEF pathogenesis?

Up‑regulated in myocardium, it impairs mitochondrial respiration and degrades #PPARγ, while deletion restores #FattyAcidOxidation and cardiac performance.

#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...