#Piezo1 links mechanical cues to bone marrow stem-cell fate. Its activation suppresses the Ccl2–CCR2–NF-κB–Lcn2 inflammatory loop, limiting adipogenesis while promoting osteoblast differentiation and #boneformation. #Osteoporosis

#STTT #OpenAccess: doi.org/10.1038/s413...

What controls the balance between #cartilage and #BoneFormation?
ST3GAL1-associated α-2,3 sialylation regulates chondrocyte and #osteoblast differentiation, with its loss impairing growth plate maturation & reducing bone mass.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...