Repairing the heart may require reprogramming immunity.
This study shows that mitochondria-rich #ExtracellularVesicles shift macrophages toward an anti-inflammatory state, improving recovery after #MyocardialInfarction. #Honokiol
#GenesAndDiseases: doi.org/10.1016/j.ge...

#PancreaticDuctalAdenocarcinoma thrives through both #tumor growth and immune suppression.
This study identifies the PKP3–P120 axis as a driver of IL-6/IL-8 signaling, tumor progression and M2 #macrophage polarization.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Genome fragility can shape disease risk.
This review highlights PARK2 as a fragile-site gene that links replication stress, #neurodegeneration, and #cancer, revealing its potential as both a biomarker and #PrecisionMedicine target.
#GenesAndDiseases: doi.org/10.1016/j.ge...

#COVID19 may leave a distinct brain signature.
This study links post-COVID brain changes to #olfactory-related regions and identifies S1 pyramidal #neuron activity as a key correlate of structural brain alterations.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

A new molecular axis may explain how #ColorectalCancer spreads to the liver.
This study reveals a Lyn–TRIB3–SOX9 axis in which #SuperEnhancers and phase separation activate MET transcription, promoting metastatic spread.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could a #RespiratorySyncytialVirus viral protein reshape infant immunity and disease severity?
This study shows extracellular NS1 promotes TH2 differentiation, linking higher NS1 levels to immune changes and disease severity.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

A new link between #inflammation and #LungFibrosis.
Macrophage-derived ECM1 amplifies fibrosis via #TGFβ/HIF signalling, driving matrix remodelling and linking higher ECM1 to poorer survival. @unisouthampton.bsky.social
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Why do #glioblastomas keep rebuilding themselves after treatment?
This review reframes glioma stemness as a dynamic state shaped by #TumourPlasticity and brain niches, offering new paths to tackle resistance and recurrence.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Persistent #StaphylococcusAureus infection can evade immune clearance & drive chronic #BoneInfection.
This study reveals α-hemolysin suppresses NF-κB signaling while evading degradation, enabling immune escape.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could tiny RNA fragments reshape #NeurologicalDisease research?
This review highlights how #tsRNAs regulate inflammation, oxidative stress and the blood–brain barrier, with potential as biomarkers & therapeutic targets. #CNS
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Reliable #AlternativeSplicing detection is key for clinical biomarkers.
This review highlights #RNAsequencing benchmarking, standardization and analytical optimization for reproducible results. #Bioinformatics
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Low potassium in #hypertension may signal heightened organ risk.
This review links #hypokalemia and low-normal #potassium to cardiovascular and renal injury, emphasizing systematic detection and cause-directed therapy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Nerve invasion changes far more than tumour spread.
Pancreatic and #BiliaryCancers exploit nerve signalling to promote growth, #metastasis, and immune evasion, revealing new targets for #PrecisionTherapy. @tsinghua_uni
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

What happens to fat tissue under #hypertension?
This study reveals #adipocyte dysfunction and macrophage inflammation driven by PPARγ/CBR3 activity, linking lipid accumulation to #CardiometabolicDisease. #WhiteAdiposeTissue
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

A newly uncovered brake on #HBV replication.
HOXD1 limits HBV transcription by suppressing #UFMylation, revealing a host defence pathway that regulates NF-κB signalling and may offer a new therapeutic target for chronic hepatitis B.
#GenesAndDiseases: doi.org/10.1016/j.ge...

#HCC’s lipid addiction fuels tumor progression, but its regulatory drivers remain unclear.
This study reveals the E2F1/LRRC1/FASN axis as a key regulator of lipid reprogramming, tumor growth and metastasis. #LipidAccumulation
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

UNC93B1 influences #autoimmunity beyond TLR trafficking.
A gain-of-function variant linked to early-onset #lupus enhances dendritic-cell activation and #AntigenPresentation, promoting T-cell differentiation and immune dysregulation.
#GenesAndDiseases: doi.org/10.1016/j.ge...

How does epigenetic dysregulation drive kidney disease?
#DNMT1 regulates renal inflammation, cell proliferation, apoptosis, #fibrosis and metabolic stress, making it a potential target for #KidneyDisease therapy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Small chemical changes can have major biological consequences.
This review links #LysineSuccinylation to #cancer, #neurodegeneration, and metabolic disease, highlighting therapies that target the enzymes controlling this modification.
#GenesAndDiseases: doi.org/10.1016/j.ge...

Can targeted nanoparticles boost gemcitabine?
Butein-loaded #PLGAnanoparticles combined with gemcitabine reduce resistance, suppress #PancreaticTumors and extend survival in PDAC models. @mayoclinicgimfl.bsky.social
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...