@castltrastondrs.medsky.networkchronic T cell receptor (TCR) signalling, together with sustained LAG3 signalling and other inhibitory receptor signalling, drives T cell dysfunction, highlighting LAG3 as a promising therapeutic targeted immunotherapy in oncology and #autoimmunity
PDF www.nature.com/articles/s41...
@jem.orgHelios is critical for Treg effector differentiation in #adipose #autoimmunity. New study from Angela M. Thornton, Ethan M. Shevach and colleagues @niaidnews.bsky.social:
rupress.org/jem/article/...
@rupress.orgIn @jem.org, Moussavi-Harami, Tartaglia, Lowell, Chan et al. report that biallelic loss-of-function variants in PTPN6, encoding the immune-regulatory phosphatase SHP1, cause #anemia & fatal lung #hyperinflammation in families from diverse ethnic backgrounds rupress.org/jem/article/...
#Autoimmunity
@jem.orgMoussavi-Harami, Tartaglia, Lowell, Chan et al. report that biallelic loss-of-function variants in PTPN6, encoding the immune-regulatory phosphatase SHP1, cause #anemia and fatal lung #hyperinflammation in families from diverse ethnic backgrounds. rupress.org/jem/article/...
@newsen.bsky.socialWerfen Unveils QUANTA Link® 5.0: Transforming Autoimmune Lab Operations with a Web-Based Platform #United_States #San_Diego #Werfen #Autoimmunity #QUANTA_Link
@rupress.orgIn @jem.org, Thornton et al. demonstrate that in #Tregs, the transcription factor Helios directly controls Tcf1, Lef1, Id3, and Bach2 to regulate effector Treg generation and terminal differentiation. Mice with Helios-deficient Tregs show #adipose -specific #autoimmunity. rupress.org/jem/article/...
@jem.orgThornton, Shevach et al. demonstrate that in #Tregs, the transcription factor Helios directly controls Tcf1, Lef1, Id3, and Bach2 to regulate effector Treg generation and terminal differentiation. Mice with Helios-deficient Tregs show #adipose -specific #autoimmunity. rupress.org/jem/article/...
@genesndiseases.bsky.socialUNC93B1 influences #autoimmunity beyond TLR trafficking.
A gain-of-function variant linked to early-onset #lupus enhances dendritic-cell activation and #AntigenPresentation, promoting T-cell differentiation and immune dysregulation.
#GenesAndDiseases: doi.org/10.1016/j.ge...
@researchdent-tums.bsky.socialCan low saliva flow indicate more than just autoantibodies in oral lichen planus? A study finds reduced saliva but no increase in anti-M3R autoantibodies in OLP patients. #OralHealth #Autoimmunity
www.rimpacts.com/rd/p?c=10058... 📄DOI: doi.org/10.1002/hsr2...
@jhumimmunity.orgHigh prevalence of #autoantibodies neutralizing type I IFNs in Japanese patients with #hepatitis C. New study from Maki Taniguchi, Satoshi Okada and colleagues (Hiroshima University):
rupress.org/jhi/article/...
@ceijournal.bsky.socialA simpler, highly specific way to detect AIH? This study shows that MF-SMA patterns on vascular smooth muscle cells are easy to recognize and match gold-standard specificity, offering a more reliable diagnostic approach. 🧬
@thelancetendo.bsky.socialPublished in The Lancet Regional Health – Southeast Asia
#Iodine nutrition, #thyroid function, & thyroid #autoimmunity four decades after Universal Salt Iodisation in India: a cross-sectional study among schoolchildren (ICMR-SALT-T 1) www.thelancet.com/journals/lan...
#OpenAccess
@stillrollingoutdoors.comNearly ten years of searching for the help I wasn't getting.
Not healed. Not in remission. No miracle narrative.
Just a steadier floor under shaky legs.
@stillrollingoutdoors.comOn medications? Your #gut and #nutrients take real hits that doctors rarely discuss. One low-cost pushback: homemade sauerkraut-style ferment #recipe as daily floor-raiser: buff.ly/14ozd60
@gracefuluniverse.bsky.social#health #womenshealth #immunology #autoimmune #ecotoxicology #epidemiology #exposome #SDGs #autoimmunity
Blood levels of cadmium (Cd)
are associated with
rheumatoid arthritis
.
journal.physa.org/index.php/fp...
@lji.orgOur 2026 LEAD Day scientific panel explores how AI, multi-omics, and increasingly data-rich approaches are changing the way we understand and treat #autoimmune and chronic disease.
#Immunology #Autoimmunity #Health #Medicine #DataScience #CompBio #AI
@jhumimmunity.orgLinkage between HLA-B8 and HLA-DQ2.5 contributes to ancestry-dependent risk for #celiacdisease. New study from Xin Long, Xiao-Fei Kong (University of Texas Southwestern) and colleagues:
rupress.org/jhi/article/...
@gracefuluniverse.bsky.social#womenshealth #health #ecology #SDGs #immunology #autoimmunity #publichealth #ecotoxicology #menopause
Autoimmune Hashimoto's thyroiditis (hypothyroidism)
Strong positive correlations between
blood lead (Pb) levels
and thyroid peroxidase antibodies
.
www.sciencedirect.com/science/arti...
@jhumimmunity.orgThe clinical utility of #exome sequencing for risk stratification in #CeliacDisease. New study from Talha Asif, Xiao-Fei Kong (University of Texas Southwestern Medical Center) and colleagues:
rupress.org/jhi/article/...
@achronicvoice.com"C-spine, nerve & #JointPain, stacked over everyday #autoimmunity chaos. Some days getting off the floor took a while, not by choice..he body that did 2,400 miles a year couldn't manage the distance from carpet to standing.": buff.ly/jKlXnQ0
by @stillrollingoutdoors.com
#ChronicPain #MondayBlogs