@genesndiseases.bsky.social#PancreaticDuctalAdenocarcinoma thrives through both #tumor growth and immune suppression.
This study identifies the PKP3–P120 axis as a driver of IL-6/IL-8 signaling, tumor progression and M2 #macrophage polarization.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
@fcp-sfpt.bsky.social
@molneurodegenadvnc.bsky.socialMild #TraumaticBrainInjury promotes chronic #cerebrovascular #inflammation and #glymphatic suppression
Max Eisenbaum, Andrew Pearson, Arianna Cembran...Corbin Bachmeier #macrophage
@sigtrans-sttt.bsky.socialA multitarget strategy may help address #TNBC heterogeneity.
Opti-hTIF1γ suppresses β-catenin, TGFβ and STAT3 signaling while downregulating CD47 and CXCL5, enhancing #macrophage phagocytosis and #antitumoractivity.
#TumorMicroenvironment #CancerBiology
#STTT #OpenAccess: doi.org/10.1038/s413...
@limes-bonn.bsky.socialNew paper out: Size-dependent #plastic exposure disrupts #macrophage function and tissue-specific #metabolism. #NatMetab @masslab.bsky.social #SchlitzerLab #ThieleLab @unibonn.bsky.social #immune #system #FattyLiverDisease
@fabmusacchio.bsky.socialHappy to see "Size-dependent #plastic exposure disrupts #macrophage function and tissue-specific #metabolism" now out in @nature.com Metabolism!
Congrats to Nikola, @mariafviola.bsky.social, @masslab.bsky.social & everyone involved 🙏 Glad to have been involved in this work!
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@bionewscentral.comA study in mice suggests that #microplastics impair #liver #macrophage function, disrupt #metabolism, and promote #FattyLiverDisease.
@longevitytech.bsky.socialResolution Therapeutics has treated its last EMERALD trial patient, putting macrophage-based therapy on track for results before year’s end.
Link as first comment.
#longevity #geroscience #macrophage #celltherapy #clinicaltrial
@blametheamygdala.comIn the blood brain barrier, an #astrocyte conspired with a platelet to destroy all #neurons. Betrayed by a #macrophage posing as a microglia trying to pickup the #EpsteinBarrVirus, it was sentenced to #apoptosis. The astrocyte was paroled and now sells used sodium to neurons. #neuroscience #stories
@jem.orgOvezgeldiyev, Trefzer, Doolan, @boucheryt.bsky.social et al. reveal a metabolic pathway linking lipid mediator production to #macrophage activation during #helminth immunity. rupress.org/jem/article/...
#Metabolism #InnateImmunity #inflammation #InfectiousDisease #HostDefense
@rupress.orgIn @jem.org, Ovezgeldiyev, Trefzer, Doolan, @boucheryt.bsky.social et al. reveal a metabolic pathway linking lipid mediator production to #macrophage activation during #helminth immunity. rupress.org/jem/article/...
#Metabolism #InnateImmunity #inflammation #InfectiousDisease #HostDefense
@jcb.orgRhomboid protease Rhbdl2 influences #macrophage recruitment and wound repair in #zebrafish. New study from Saroj Gourkanti, Sonya E. Neal @neal-lab.bsky.social @ucsdhealthsci.bsky.social and colleagues:
rupress.org/jcb/article/...
@wisdeppes.bsky.socialCutting-edge new paper by Kitsberg et al.:
Viral entry shapes HCMV latency establishment
# Human cytomegalovirus
# herpesvirus
Fig.1a
@jcb.orgGourkanti et al. @neal-lab.bsky.social show that the rhomboid protease Rhbdl2 restrains #macrophage recruitment & wound repair in #zebrafish, positioning Rhbdl2 as a potential brake on macrophage-driven repair rupress.org/jcb/article/...
@rupress.orgIn @jcb.org, Gourkanti et al. @neal-lab.bsky.social show that the rhomboid protease Rhbdl2 restrains #macrophage recruitment & wound repair in #zebrafish, positioning Rhbdl2 as a potential brake on macrophage-driven repair rupress.org/jcb/article/...
@nicolasavilalab.bsky.socialImportantly, this relationship extends to #humans. Analysis of public snRNA-seq datasets showed that higher #mitochondrial gene expression in human 👫 #myofibers is associated with greater #macrophage abundance in the same samples
@nicolasavilalab.bsky.socialThrilled to share our latest work, out in @sciimmunology.bsky.social ! We show that tissues match their #macrophage numbers to #mitochondrial_activity , ensuring efficient #waste_clearance and #tissue_fitness . A tour de force by Laura Pena-Couso, in collab with @drusqui.bsky.social & Pura Muñoz🧵
@bocascientificinc.bsky.socialResearchers @cicsnews.bsky.social leveraged our SilenceMag to #transfect macrophages with RSK1-targeting #siRNAs, enabling RSK1 knockdown to investigate the role of RSK1 in #macrophage activation.
See it on our website here: bocascientific.com/products/sm0...
www.science.org/doi/10.1126/...