CDK12/13 inhibition exposes a vulnerability in platinum-resistant #OvarianCancer by disrupting transcription and #AlternativeSplicing, with the CDK12–SFPQ/p54nrb complex driving RNA-processing reprogramming and cytotoxicity.

#STTT #OpenAccess: doi.org/10.1038/s413...

Reliable #AlternativeSplicing detection is key for clinical biomarkers.
This review highlights #RNAsequencing benchmarking, standardization and analytical optimization for reproducible results. #Bioinformatics
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Join us at #SPLICING2027 to dig into the mechanisms behind it: from spliceosome biology to translational applications.
📅 11-15 July 2027 |📍Caparica, Portugal
📝 Registration deadline: 1 Dec. 2026
🔗 splicing2027.com
#RNASplicing #DNASplicing #AlternativeSplicing @laqv-requimte.bsky.social

Platinum resistance limits effective treatment for #OvarianCancer.

CDK12i synergizes with Pt-therapy disrupting transcriptional elongation and SFPQ/p54nrb-dependent #AlternativeSplicing, highlighting it as a potent therapeutic strategy.

#STTT #OpenAccess: doi.org/10.1038/s413...

Could one splicing regulator shape #HeartFailure?
This study identifies RBM27 as essential for maintaining Tnnt2 splicing and cardiac function, revealing a promising therapeutic target for heart disease. #AlternativeSplicing
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...