@currentmedscience.bsky.social#mRNAVaccines hold promise in #Oncology.
This review highlights RNA design, lipid nanoparticle delivery, antigen encoding, and immunomodulators as strategies to overcome TME barriers in cancer #immunotherapy. #medsky
To read: doi.org/10.1007/s115...
@currentmedscience.bsky.socialBy analyzing #CD8+, CD4+, NKT, and γδ T cells, this study underscores the promise of TCR‑T, #CART, and checkpoint inhibitors in achieving long‑term AML control and advancing future therapeutic strategies. #medsky
To read: doi.org/10.1007/s115...
@currentmedscience.bsky.socialStudy links decreased Akkermansia with higher inflammatory risk in unstable angina, pointing to the microbiota’s role in disease & the need for mechanistic clarity. @2024_HUST
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@currentmedscience.bsky.socialThis review highlights altered tryptophan #Metabolism in #obesity, underscoring its potential as a therapeutic target for metabolic and psychological comorbidities. #medsky
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@currentmedscience.bsky.socialReciprocal activation between S100A9 and TLR2 amplifies hypertrophic signaling in mechanically stretched #cardiomyocytes, exacerbating maladaptive remodeling and likely accelerating HF progression, highlighting therapeutic targets. #medsky
To read: doi.org/10.1007/s115...
@currentmedscience.bsky.socialThe global burden of PAH is rising unevenly, with high SDI regions seeing more cases. The study calls for equitable resources and better diagnostics. #medsky
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#currentmedicalscience #Cardiology #HealthEquity #GlobalHealth
@currentmedscience.bsky.socialCombination therapy shows promise in #schistosomiasis care.
YCHD and PZQ reduce #granulomatous inflammation and #fibrosis by inhibiting apoptosis and ER stress, offering therapeutic promise. #medsky
To read: doi.org/10.1007/s115...
#currentmedicalscience #Hepatology
@currentmedscience.bsky.socialThe #MUFA content of #Avocado oil varies by cultivar.
This study highlights metabolic promise but calls for standardization of therapeutic applications across cultivars. #medsky
To read: doi.org/10.1007/s115...
@currentmedscience.bsky.socialThis study demonstrates that #CHOP deficiency intensifies inflammation, epithelial #apoptosis, and injury in OAB mice by suppressing #ERStress, pointing to CHOP as a therapeutic axis. #medsky
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@currentmedscience.bsky.socialThis study summarizes the role of #TranscriptionFactors in #ALD pathology—from lipid metabolism to ER stress—and highlights promising targeted therapies for ALD treatment. #medsky
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@currentmedscience.bsky.socialSIC raises mortality; pre‑SIC increases risk.
A #nomogram-based prediction model enables early SIC identification, improving #sepsis management & outcomes. #medsky
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@currentmedscience.bsky.socialCan a natural compound protect the #Liver from alcohol induced iron overload?
This study reveals that #quercetin sustains ferritinophagic flux & lysosomal function via #FOXO1 TFEB NCOA4 signaling. #medsky
To read: doi.org/10.1007/s115...
@currentmedscience.bsky.socialSAE drives high morbidity and mortality. This review shows how #lncRNAs modulate #inflammation, metabolism, and immune function — impacting the blood brain barrier and neurons. #medsky
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@currentmedscience.bsky.social#Multiomics analysis links #Ferroptosis risk groups to HCC’s immune microenvironment. #GRINA inhibition induces mitochondrial damage & ferroptosis in HCC cells, offering a novel therapeutic strategy. #medsky
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@currentmedscience.bsky.social#PMEPA1 impairs Treg‑mediated #immunosuppression by hyperactivating PI3K/AKT, fueling ESC invasiveness in #Endometriosis. Targeting this axis may restore immune balance and curb progression. #medsky
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@currentmedscience.bsky.socialThis review highlights #sialylation as a key regulator of OC progression, metastasis, and drug resistance, pointing toward novel therapeutic strategies. #medsky
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@currentmedscience.bsky.socialThis review highlights how #optogenetics dissects neural mechanisms using light to precisely activate or inhibit specific neurons, combined with behavioral & #electrophysiological analyses. #medsky
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@currentmedscience.bsky.social#miR146a plays a central role in #neuroinflammation across NDDs. This review highlights its promise as both a biomarker and therapeutic target, paving the way for precision #Neurology. #medsky
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@currentmedscience.bsky.socialSystematic review shows how #AI can transform #TraditionalChineseMedicine practices into structured clinical decision systems, enhancing medical decision-making. #medsky
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@currentmedscience.bsky.socialAR-positive #TNBC offers a vital target, but single-agent anti-AR therapies hit steep clinical hurdles. This review outlines how combining AR antagonists with other therapeutic strategies overcomes resistance. #medsky
To read: doi.org/10.1007/s115...
