“Chondroitin sulfate shapes the unfolded protein response in osteosarcoma to sustain cancer cell survival during ER stress”

Read more about the regulatory and functional relationships between oncofetal CS and #ERStress in #Osteosarcoma ⤵️
nature.com/articles/s41...

This study uncovers how polymeric #Alpha1Antitrypsin accumulation perturbs Paneth cell #Proteostasis via #ERstress and impaired lysosomal clearance, linking deficiency to severe intestinal inflammation.

#STTT #OpenAccess: doi.org/10.1038/s413...

This study demonstrates that #CHOP deficiency intensifies inflammation, epithelial #apoptosis, and injury in OAB mice by suppressing #ERStress, pointing to CHOP as a therapeutic axis. #medsky

Read more: doi.org/10.1007/s115...

#currentmedicalscience #Urology