@stephanhacker2.bsky.social
Assistant Professor at Leiden University. Covalent inhibitors and chemoproteomics for antibiotics. Views my own. he/him/his. https://orcid.org/0000-0001-5420-4824
@stephanhacker2.bsky.socialI am excited to meet a large number of amazing scientists, talk science and present our latest work.
I will also use the trip to cross one item of my bucket list by watching a Michigan Football game at The Big House.
#ChemSky #ChemBio #Science #Football #BucketList
(5/5)
@stephanhacker2.bsky.social...
- an invited talk at the 4th Annual Drug Discovery and Development Summit in Boston, covalent-drug-discov...
- a department visit at @yale.edu invited by @jeanjuchung.bsky.social and Wenxin Felix Zhu
(4/5)
@stephanhacker2.bsky.social...
- a department visit at UCSF invited by Balyn Zaro
- a department visit at @umich.edu invited by Alexey Nesvizhskii and Fengchao
...
(3/5)
@stephanhacker2.bsky.socialThe trip will include:
- an invited talk at the ICBS conference in San Francisco, www.chemical-biology...
- a department visit at UCLA invited by Keri Backus
...
(2/5)
@stephanhacker2.bsky.socialVery excited to be traveling back to the USA for the first time since the end of my postdoc with Ben Cravatt in 2017. It is going to be a big one with 2 conferences, 4 department visits and 6 talks over the next two weeks. Looking forward to a great (and probably also exhausting) trip. (1/5)
@stephanhacker2.bsky.socialNew paper by the group of Lyn Jones. They study the amino acid reactivity and plasma stability of sulfonyl imidazole (SuDEx) and triazole (SuTEx) electrophiles showing enhanced stability and tyrosine reactivity for SuDEx.
@stephanhacker2.bsky.socialNew paper by the group of Lyn Jones. They study the amino acid reactivity and plasma stability of sulfonyl imidazole (SuDEx) and triazole (SuTEx) electrophiles showing enhanced stability and tyrosine reactivity for SuDEx.
@stephanhacker2.bsky.socialAre PROTACs that engage target proteins in an irreversibly covalent manner viable?
A new Nature Communications paper by the groups of Jin Wang and Xiaoli Qi now convincingly shows potent BTK degradation employing an irreversible BTK ligand.
@stephanhacker2.bsky.socialI had a great time and hope to be back for the next event in 2028.
#CovalentInhibitor #DrugDiscovery #ChemicalProteomics #ChemBio #Chemistry #Science
(7/7)
@stephanhacker2.bsky.social... Amanda Ferdinand Madeeha Ali Syed Darrin McKenzie Federica Raguseo (@federicaraguseo.bsky.social) Chloe Oxford Yoav Shamir Craig Malcolm Tom Ruane (@tomruane.bsky.social) (6/7)
@stephanhacker2.bsky.social...
Matthew Bogyo (@mbogyo.bsky.social)
Scott Lovell
David Heppner (@heppnerd.bsky.social)
William McCarthy (@william-mccarthy.bsky.social)
Jonathan Pettinger
Michael Bodnarchuk
...
(5/7)
@stephanhacker2.bsky.socialWe also had an amazing speaker program: Matthias Gehringer Louise Walport (@ljwalport.bsky.social) Megan Wright (@meganwright.bsky.social) Matthew Bilyard Ed Tate Steven Gygi ... (4/7)
@stephanhacker2.bsky.socialI want to specifically highlight the outstanding quality of the poster sessions. Thank you to all presenters for sharing their exciting work. (3/7)
@stephanhacker2.bsky.socialA huge thank you to the @britpharmsoc.bsky.social and especially Bonnie Rayner, Sarah Hewitt, Sam Rowe and Simon Lucas for putting together this amazing event.
(2/7)
@stephanhacker2.bsky.socialThe Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov was an amazing meeting.
I am very happy that I was invited to present some of our most recent work.
Photo credit: @aekiib.bsky.social
(1/7)
@stephanhacker2.bsky.socialA true firework of covalent drug discovery to close out the Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov!
Ed Tate presented a variety of exciting projects of his group.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@stephanhacker2.bsky.socialInteresting talk by Michael Bodnarchuk from @astra-zeneca.bsky.social at #CovModDrugDiscov.
He talked about the use of computational tools to discover covalent, brain-penetrant KRAS G12C inhibitors.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@stephanhacker2.bsky.socialExciting talk by Yoav Shamir from the group of Nir London at #CovModDrugDisvov!
He talked about cofolding in Alphafold3 to identify #CovalentInhibitors with novel structures for BTK.
#DrugDiscovery #Kinase #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialInteresting talk by Chloe Oxford from GSK at #CovModDrugDiscov.
She talked about a MALDI-TOF-MS-based assay to characterize the binding of #CovalentInhibitors to challenging proteins with resolution of the binding site.
@stephanhacker2.bsky.socialInteresting talk by Federica Raguseo at #CovModDrugDiscov.
She talked about a phenotype-first approach to covalent drug discovery on the example of TYMS.
www.biorxiv.org/content/10.6...
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
