@heppnerd.bsky.social
Medicinal Chemistry 💊 | Drug Discovery 💡 | Cancer Biology 🧫 | Structural Biology 🧬 The State University of New York at Buffalo 🦬
@stephanhacker2.bsky.socialReposted by @heppnerd.bsky.socialGreat talk by David Heppner (@heppnerd.bsky.social) at #CovModDrugDiscov.
He gave exciting insights into rigorously characterizing #CovalentInhibitors using crystal structures and kinetics.
@heppnerd.bsky.socialGreatly looking forward to joining this crew tomorrow!!
@stephanhacker2.bsky.socialReposted by @heppnerd.bsky.socialHow can covalency be used in the most effective way to accelerate drug discovery?
I am very happy to be on the way to the conference "Covalent Modulation in Drug Discovery" by the @britpharmsoc.bsky.social in Cambridge to discuss this and related question in the coming two days.
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@heppnerd.bsky.socialNew work published today in @angewandtechemie.bsky.social (Very Important Paper) on gaining drug selectivity by "Thinking Outside the Binding Site." onlinelibrary.wiley.com/doi/10.1002/...
@sciencex.bsky.socialReposted by @heppnerd.bsky.socialA p38 delta inhibitor achieved 12,000-fold greater selectivity by causing a flexible protein loop to kink and wrap around it. A distant amino acid helps stabilize this unusual fit. doi.org/hcjqf7
