I had a great time and hope to be back for the next event in 2028.
#CovalentInhibitor #DrugDiscovery #ChemicalProteomics #ChemBio #Chemistry #Science
(7/7)
@stephanhacker2.bsky.social
@stephanhacker2.bsky.socialI had a great time and hope to be back for the next event in 2028.
#CovalentInhibitor #DrugDiscovery #ChemicalProteomics #ChemBio #Chemistry #Science
(7/7)
@stephanhacker2.bsky.socialA true firework of covalent drug discovery to close out the Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov!
Ed Tate presented a variety of exciting projects of his group.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@stephanhacker2.bsky.socialInteresting talk by Michael Bodnarchuk from @astra-zeneca.bsky.social at #CovModDrugDiscov.
He talked about the use of computational tools to discover covalent, brain-penetrant KRAS G12C inhibitors.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@stephanhacker2.bsky.socialInteresting talk by Federica Raguseo at #CovModDrugDiscov.
She talked about a phenotype-first approach to covalent drug discovery on the example of TYMS.
www.biorxiv.org/content/10.6...
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialInteresting talk by Darrin McKenzie at #CovModDrugDiscov.
He talked about, how they set up an automated platform to study protein expression levels and cysteine engagement in living cells.
#CovalentInhibitor #DrugDiscovery #ChemBio #ChemSky #ChemicalProteomics #Science
@stephanhacker2.bsky.socialAlways great to see the amazing work by Patrick Zanon in our group highlighted in the talk of others.
www.nature.com/articles/s41...
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science #ChemPro #ProteoProbes
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialThe 2nd day of #CovModDrugDiscov gets on the way with an inspiring talk by Steven Gygi.
He talked about the power of TMT technologies for multiplexing to arrive at high-throughput residue-specific chemoproteomics.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #ChemicalProteomics #Science
@stephanhacker2.bsky.socialInsightful talk by Matthias Gehringer at #CovModDrugDiscov.
He gave great insights into his group's work on making new kinases amenable to covalent drug discovery at cysteine and beyond.
onlinelibrary.wiley.com/doi/10.1002/...
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science #Kinase
@stephanhacker2.bsky.social#CovModDrugDiscov continues with an interesting talk by Mandy Ferdinand from Cancer Research Horizons.
She talked about methods to characterize covalent hits with a special focus on binding kinetics.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@stephanhacker2.bsky.socialThe Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov is off to a great start with an insightful talk by Matt Bilyard from Roche.
He talked about how they select targets for covalent drug discovery and then find and develop covalent binders.
@stephanhacker2.bsky.socialAnd we are on the way with the Covalent Modulation in Drug Disvovery Conference by @britpharmsoc.bsky.social.
Looking forward to two days filled with cutting-edge covalent drug discovery.
@stephanhacker2.bsky.socialI am looking forward to an exciting meeting.
#CovalentInhibitor #DrugDiscovery #ChemSky #Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes
(3/3)
@stephanhacker2.bsky.socialInteresting paper by the groups of Bradley Pentelute and Aaron Nile in Chemical Science.
They developed an on-resin, intermolecular Heck reaction to diversify acrylamides for covalent hit discovery using coPELs.
