Exciting talk by Yoav Shamir from the group of Nir London at #CovModDrugDisvov!

He talked about cofolding in Alphafold3 to identify #CovalentInhibitors with novel structures for BTK.

pubs.acs.org/jacsat/artic...

#DrugDiscovery #Kinase #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social

Interesting talk by Chloe Oxford from GSK at #CovModDrugDiscov.

She talked about a MALDI-TOF-MS-based assay to characterize the binding of #CovalentInhibitors to challenging proteins with resolution of the binding site.

#DrugDiscovery #ChemBio #ChemSky #Science

Interesting talk by @ljwalport.bsky.social at #CovModDrugDiscov.

She talked about the discovery of potent peptide-based #CovalentInhibitors using mRNA display.

www.nature.com/articles/s42...

#mRNA #RNA #DrugDiscovery #ChemBio #ChemSky #Science
@britpharmsoc.bsky.social

Interesting talk by Madeeha Ali at #CovModDrugDiscov.

She talked about her exciting work on studying the kinetics of #CovalentInhibitors.

bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

#DrugDiscovery #Kinetics #ChemSky #ChemBio

Great talk by David Heppner (@heppnerd.bsky.social) at #CovModDrugDiscov.

He gave exciting insights into rigorously characterizing #CovalentInhibitors using crystal structures and kinetics.

pubs.acs.org/abmcb8/artic...

#DrugDiscovery #ChemSky #ChemBio #Science

Interesting talk by Jonathan Pettinger from GSK at #CovModDrugDiscov.

He talked about the power of direct-to-biology (D2B) approaches for fast SAR studies of #CovalentInhibitors.

chemrxiv.org/doi/10.26434...

#D2B #DirectToBiology #DrugDiscovery #ChemBio #ChemSky #Science