Exciting talk by Yoav Shamir from the group of Nir London at #CovModDrugDisvov!

He talked about cofolding in Alphafold3 to identify #CovalentInhibitors with novel structures for BTK.

pubs.acs.org/jacsat/artic...

#DrugDiscovery #Kinase #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social

Insightful talk by Matthias Gehringer at #CovModDrugDiscov.

He gave great insights into his group's work on making new kinases amenable to covalent drug discovery at cysteine and beyond.

onlinelibrary.wiley.com/doi/10.1002/...

#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science #Kinase

Good #medchem example of targeting pseudokinases to #allosteric-ally regulate #PPI / #kinase activity. Reassuring is decent kinome selectivity despite targeting the ATP-binding site, and would love to see further development of C160 covalent activators.

www.cell.com/cell-chemica...