The Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov was an amazing meeting.
I am very happy that I was invited to present some of our most recent work.
Photo credit: @aekiib.bsky.social
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@stephanhacker2.bsky.social
@stephanhacker2.bsky.socialThe Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov was an amazing meeting.
I am very happy that I was invited to present some of our most recent work.
Photo credit: @aekiib.bsky.social
(1/7)
@stephanhacker2.bsky.socialA true firework of covalent drug discovery to close out the Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov!
Ed Tate presented a variety of exciting projects of his group.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@stephanhacker2.bsky.socialInteresting talk by Michael Bodnarchuk from @astra-zeneca.bsky.social at #CovModDrugDiscov.
He talked about the use of computational tools to discover covalent, brain-penetrant KRAS G12C inhibitors.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@stephanhacker2.bsky.socialInteresting talk by Chloe Oxford from GSK at #CovModDrugDiscov.
She talked about a MALDI-TOF-MS-based assay to characterize the binding of #CovalentInhibitors to challenging proteins with resolution of the binding site.
@stephanhacker2.bsky.socialInteresting talk by Federica Raguseo at #CovModDrugDiscov.
She talked about a phenotype-first approach to covalent drug discovery on the example of TYMS.
www.biorxiv.org/content/10.6...
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialExciting talk by @meganwright.bsky.social at #CovModDrugDiscov.
She talked about new chemical methods to make libraries of covalent compounds and using them in MS-based and phenotypic screens.
#DrugDiscovery #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialInteresting talk by Darrin McKenzie at #CovModDrugDiscov.
He talked about, how they set up an automated platform to study protein expression levels and cysteine engagement in living cells.
#CovalentInhibitor #DrugDiscovery #ChemBio #ChemSky #ChemicalProteomics #Science
@stephanhacker2.bsky.socialExciting talk by William McCarthy at #CovModDrugDiscov.
He talked about their amazing capacities at the Francis Crick Institute for #chemoproteomic profiling of cysteines. Great insights into the use of #MachineLearning to predict more selective compounds. (1/2)
@stephanhacker2.bsky.socialThe 2nd day of #CovModDrugDiscov gets on the way with an inspiring talk by Steven Gygi.
He talked about the power of TMT technologies for multiplexing to arrive at high-throughput residue-specific chemoproteomics.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #ChemicalProteomics #Science
@stephanhacker2.bsky.socialThe first day of #CovModDrugDiscov comes to an end with an exciting talk by @mbogyo.bsky.social.
He talked about covalent probes to visualize bacterial infections and tumors. Great to see them take this concept to phase 3 studies for fluorescence-guided surgery.
@stephanhacker2.bsky.socialInspiring talk by Scott Lovell at #CovModDrugDiscov.
He talked about the development of macrocyclic #peptides into covalent inhibitors targeting lysines using SuFEx chemistry.
www.biorxiv.org/content/10.6...
#DrugDiscovery #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialInteresting talk by @ljwalport.bsky.social at #CovModDrugDiscov.
She talked about the discovery of potent peptide-based #CovalentInhibitors using mRNA display.
www.nature.com/articles/s42...
#mRNA #RNA #DrugDiscovery #ChemBio #ChemSky #Science
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialInteresting talk by Madeeha Ali at #CovModDrugDiscov.
She talked about her exciting work on studying the kinetics of #CovalentInhibitors.
@stephanhacker2.bsky.socialGreat talk by David Heppner (@heppnerd.bsky.social) at #CovModDrugDiscov.
He gave exciting insights into rigorously characterizing #CovalentInhibitors using crystal structures and kinetics.
@stephanhacker2.bsky.socialInsightful talk by Matthias Gehringer at #CovModDrugDiscov.
He gave great insights into his group's work on making new kinases amenable to covalent drug discovery at cysteine and beyond.
onlinelibrary.wiley.com/doi/10.1002/...
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science #Kinase
@stephanhacker2.bsky.socialWe had an amazing poster session at #CovModDrugDiscov! I learned a lot about new warheads, covalent binder optimization and methods to measure target engagement.
Thank you to all presenters for sharing their amazing science.
#DrugDiscovery #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialInteresting talk by Jonathan Pettinger from GSK at #CovModDrugDiscov.
He talked about the power of direct-to-biology (D2B) approaches for fast SAR studies of #CovalentInhibitors.
#D2B #DirectToBiology #DrugDiscovery #ChemBio #ChemSky #Science
@stephanhacker2.bsky.social#CovModDrugDiscov continues with an interesting talk by Mandy Ferdinand from Cancer Research Horizons.
She talked about methods to characterize covalent hits with a special focus on binding kinetics.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@stephanhacker2.bsky.socialThe Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov is off to a great start with an insightful talk by Matt Bilyard from Roche.
He talked about how they select targets for covalent drug discovery and then find and develop covalent binders.
