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@cemm.oeaw.ac.at Oct 1, 2026, 1:02 PM

🎓 From around the world to Vienna: #CeMM welcomes its 2026 cohort of international #PhD students! Ready to collaborate, discover & push the boundaries of #molecularmedicine together. 👩‍🔬👨🏿‍🔬

@tenuretracker.bsky.social Sep 28, 2026, 9:32 AM

The Ohio State University is hiring:
Research Scientist - Molecular Medicine & Therapeutics

#researcher #medicine #molecularmedicine

@sigtrans-sttt.bsky.social Sep 27, 2026, 6:45 AM

USP2 inhibition destabilizes STUB1 to suppress pathological #Pexophagy in PEX1-deficient models, restoring peroxisome abundance while mitigating metabolic abnormalities, neuro-axonal pathology, and motor dysfunction.

#STTT #OpenAccess: doi.org/10.1038/s413...
#Neurobiology #MolecularMedicine

Inhibition of USP2 suppresses pathological pexophagy and rescues PEX1-deficient peroxisome biogenesis disorder

@northwell-journals.bsky.social Sep 23, 2026, 4:37 PM

Molecular Medicine - Journal

Article in Press: Urinary collagen type I degradation products as common fibrosis biomarkers in chronic diseases | #MolecularMedicine #Fibrosis #Biomarkers #CKD link.springer.com/article/10.1...

@northwell-journals.bsky.social Sep 23, 2026, 4:36 PM

Molecular Medicine - Journal
Article in Press: Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma | #MolecularMedicine #HDAC #UvealMelanoma #Proteogenomics link.springer.com/article/10.1...

@northwell-journals.bsky.social Sep 23, 2026, 4:35 PM

Molecular Medicine - Journal
Article in Press: Oxidative stress and endothelial dysfunction: linking cellular damage to cardiovascular disease and erectile dysfunction | #MolecularMedicine #CVD #ED #OxidativeStress #EndothelialDysfunction link.springer.com/article/10.1...

Fig. 1 Cardiovascular sources of ROS. The primary sources of reactive oxygen species (ROS) in the cardiovascular system include mitochondrial dysfunction, NADPH oxidases (NOX), xanthine oxidase (XO), and uncoupled endothelial nitric oxide synthase (eNOS). A Triggers, such as chronic inflammation and hyperglycemia, cause mitochondrial membrane potential loss, which induces leakage of free radicals like superoxide anions and hydroxyl radicals. B In the presence of xanthine oxidase, hypoxic conditions may also activate the conversion of xanthine and hypoxanthine to uric acid, which is a potent pro-oxidant. C In addition, inflammatory mediators activates NADPH oxidases (NOX) to produce free radicals. D Under pathological conditions, such as dyslipidaemia or renal impairment, eNOS becomes uncoupled and produce superoxide instead of nitric oxide, in the presence of cofactors like as tetrahydrobiopterin (BH4). (E) Metabolic and inflammatory pathological amplifiers, such as diabetes and ......

@northwell-journals.bsky.social Sep 23, 2026, 4:34 PM

Molecular Medicine - Journal
Bioengineered microtissue model of the human nigrostriatal pathway featuring centimeter-scale axon tracts and structural maturation over 6 months in vitro | #MolecularMedicine #Bioengineering #iPSC #inVitroModels #DopaminergicNeurons link.springer.com/article/10.1...

Fig. 1 Assessment and comparison of aggregated human iPSC-derived DA neuronal cultures on different coating surfaces.
Representative confocal images show comparison of neurite growth pattern of DA neurons (110,000 cells/aggregate) on ...
D- Immunocytochemistry (ICC) images validate DA neuronal markers such as βIII-tubulin (all axons, green), MAP2 (Microtubule-Associated Protein 2; soma and dendrites, gray) and TH (Tyrosine Hydroxylase; DA axons, red). E -Magnified images shown in the inset: enlarged overlay image (top) and individual channel images (bottom) highlight robust DA neuronal markers in the aggregate. F -Magnified images of peripheral neurites shown in the inset demonstrate individual
channel images of TH and βIII-tubulin.

@northwell-journals.bsky.social Sep 23, 2026, 4:06 PM

Molecular Medicine - Journal

Article in Press: Bacterial communication in the gut: interbacterial and bacteria-host crosstalk | #MolecularMedicine #BacterialCommunication #MicrobialCrosstalk #GutMicrobiome link.springer.com/article/10.1...

Fig. 3 Influencing factors on bacterial communication. Bacterial communication is regulated by diverse factors originating from bacteria, gut microenvironment and signaling molecules.
A. Overview of factors influencing bacterial communication, in which
bacterial-derived elements include population density and mutant
strains, gut environmental regulators comprise antibiotics, pH, gut
motility and host immunity, and signaling molecules are modulated
by their diffusion mode and rate as well as competitive inhibition.

@northwell-journals.bsky.social Sep 23, 2026, 4:05 PM

Molecular Medicine - Journal

Article in Press: Multi-omics in systemic sclerosis with emphasis on extracellular vesicles | #MolecularMedicine #ExtracellularVesicles #Multiomics #SystemicSclerosis link.springer.com/article/10.1...

Fig. 2 Schematic summary of the major metabolic pathways that are dysregulated in SSc. In each pathway (amino acid metabolism, lipid metabolism, mitochondrial metabolism, carbohydrate metabolism), the metabolites whose expression has been found to be modulated in patients’ plasma are listed. The impacted pathophysiological pathways are indicated (fibrosis in orange, immune alteration in violet and vascular dysfunction in red). TCA: Tricarboxylic Acid Cycle; GLUT-1: Glutamate Transporter-1

@northwell-journals.bsky.social Sep 23, 2026, 4:04 PM

Molecular Medicine - Journal

Article in Press: Dysregulation of DNA replication licensing factors in cancer | #MolecularMedicine #Cancer #PrereplicativeComplex link.springer.com/article/10.1...

@northwell-journals.bsky.social Sep 23, 2026, 4:03 PM

Molecular Medicine - Journal

Article in Press: Pericytes within tumour and other angiogenic microenvironments as potential targets for therapeutic viruses | #MolecularMedicine #Pericytes #CancerAngiogenesis #OncolyticViruses link.springer.com/article/10.1...

Fig. 1 Pericytes are infected by VSV following systemic VSV treatment. A Schematic of imaging experiment timeline.

@northwell-journals.bsky.social Sep 23, 2026, 3:38 PM

Molecular Medicine - Journal

Article in Press: Dopamine alters macrophage metabolism promoting intracellular Mycobacterium tuberculosis survival | #MolecularMedicine #dopamine #tuberculosis #macrophages link.springer.com/article/10.1...

Fig. 1 Dopamine induces accumulation of iron in macrophages. A-C Cellular labile iron pool evaluated in macrophages using Calcein AM staining and flowcytometry. (A) THP-1 macrophages and (B) mice primary peritoneal macrophages (PMQ). THP-1 and PMQ were treated with different concentrations of dopamine for 24 h in culture. The intracellular labile iron pool is significantly increased upon incubation with 250 µM DA. Data is presented as MFI ± SD (upper panels). Statistical significance was evaluated using unpaired t-test (n = 3 *p < 0.05, **p < 0.01). All Experiments were repeated three times and one representative data is presented. Lower panels depict one representative FACS overlay histograms plotted for data from n = 104 cells per histogram using flowjo software. C The labile iron pool is also significantly elevated in PMQ isolated from mice administered DA for 3 days. C57 BL/6 mice were injected i.p with 5 mg/kg DA in 200 ul PBS every 12 h for 3 days. Control represents cell....

@northwell-journals.bsky.social Sep 23, 2026, 3:37 PM

Molecular Medicine - Journal
Article in Press: TGF-β1 signaling in Crohn’s disease | #MolecularMedicine #TGFbeta #CrohnsDisease link.springer.com/article/10.1...

@tenuretracker.bsky.social Sep 18, 2026, 10:42 PM

UT Southwestern Medical Center is hiring:
Tenure Track Assistant Professor in Molecular Medicine

#assistantprofessor #medicine #molecularmedicine

@northwell-journals.bsky.social Sep 16, 2026, 6:50 PM

Molecular Medicine - Journal
Article in Press: Development and validation of a 10-metabolite prognostic model for 4-year all-cause mortality in heart failure with preserved ejection fraction in the Chinese Han population | #MolecularMedicine #HeartFailure #HFpEF link.springer.com/article/10.1...

Fig. 4 The core part of metabolic responses extracted from the metabolic network (Supplementary Figure S9 and S10) constructed based on metabolomics and transcriptomics

@northwell-journals.bsky.social Sep 16, 2026, 6:49 PM

Molecular Medicine - Journal
Article in Press: Metabolism-guided precision oncology in hepatocellular carcinoma: vascular, stromal and immune crosstalk | #MolecularMedicine #HepatocelluarCarcinoma #HCC #Metabolomics link.springer.com/article/10.1...

Fig. 6 Therapeutic strategies targeting metabolic–vascular interactions in HCC. This schematic summarizes therapeutic concepts that arise from metabolism–vascular crosstalk in HCC. The figure is organized into four modules: tumor-intrinsic metabolic targets, endothelial cell metabolism and angiogenesis, stromal and myeloid targeting, and rational combination strategies. Tumor-intrinsic metabolic interventions include inhibition of lactate production, lactate transport, glycolytic enzymes, glutamine metabolism, fatty-acid oxidation, and lactylation-associated signaling. Endothelial-directed strategies include anti-VEGF/VEGFR therapies, PFKFB3 inhibition, and modulation of endothelial barrier function. Stromal and myeloid strategies include TAM repolarization, lactylation-related targeting, TGF-β inhibition, CAF modulation, and periostin blockade. The combination module illustrates how metabolic interventions may be paired with anti-angiogenic therapy or PD-1/PD-L1 blockade to enhance vascular normalization and anti-tumor immunity. Approved anti-angiogenic and immunecheckpoint therapies are shown as established clinical backbones, whereas metabolic, stromal, lactylation-associated, and CAF/TAM-directed strategies should be interpreted as investigational or preclinical candidates for biomarker-enriched testing rather than as established treatment options. Approved agents are shown in solid blue boxes, whereas investigational and preclinical strategies are shown in gray boxes with dashed outlines.

@northwell-journals.bsky.social Sep 16, 2026, 6:46 PM

Molecular Medicine - Journal
Article in Press: Meta-transcriptomic analysis identifies suppressed FGF/FGFR signaling as a consistent molecular feature of impaired angiogenic repair in Diabetic Foot Ulcers | #MolecularMedicine #DiabeticFootUlcers #FGF link.springer.com/article/10.1...

Fig. 12 1) Integrated transcriptomic analysis of each microarray and RNA-seq cohort reveals convergent DFU signature with downregulated DEGs enriched for epidermal differentiation, keratinization and extracellular matrix organization gene ontology terms; 2) Gene set variation analysis (GSVA) and Protein–protein interaction networks (PPIN) indicated FGF/FGFR network components are downregulated in DFU; 3) Weighted gene co-expression network analysis (WGCNA) showed a module associated with inflammatory activation positively correlated with DFU status in the microarray cohort, while FGF/FGFR signaling modules were negatively correlated with DFU status in the RNA-seq cohort, Cell-type enrichment analysis revealed reduced stromal and reparative cell populations in the wound microenvironment.; 4) DFU diagnostic model tested and validated across microarray and RNA-seq cohorts identified nine marker genes in a random forest classifier. Among commonly up-regulated DEGs, SERPINE1 was highlig...

@northwell-journals.bsky.social Sep 16, 2026, 6:45 PM

Molecular Medicine - Journal
Article in Press: USP7-mediated stabilization of Snail1 drives macrophage-to-myofibroblast transition and promotes postoperative peritoneal adhesions | #MolecularMedicine #PostoperativePeritonealAdhesions #Surgery #Olaparib link.springer.com/article/10.1...

@xiahepublishing.bsky.social Sep 10, 2026, 5:30 PM

🔬 A new molecular study links altered gene regulation to clinically relevant disease mechanisms. @embl.org
#MolecularMedicine #Genomics
🔗 www.xiahepublishing.com/1555-3884/GE...

@northwell-journals.bsky.social Sep 10, 2026, 3:55 PM

Molecular Medicine - Journal
Article in Press: Endoplasmic reticulum stress-mediated PPARα-DDX3X interaction promotes immune-induced liver injury | #MolecularMedicine #PPAR #EndoplasmicReticulum #ImmuneSystem #LiverInjury