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@narrowit.bsky.socialOct 5, 2026, 10:40 AM

AROA Trial Finds Higher Diabetic Foot Ulcer Closure With Symphony AROA reported statistically significant gains in diabetic-foot-ulcer...

https://www.narrowit.com/news/aroa-symphony-diabetic-foot-ulcer-randomized-trial-2026-10-05
#AroaBiosurgery #Symphony #DiabeticFootUlcers #RandomizedTrial

@northwell-journals.bsky.socialSep 16, 2026, 6:46 PM

Molecular Medicine - Journal
Article in Press: Meta-transcriptomic analysis identifies suppressed FGF/FGFR signaling as a consistent molecular feature of impaired angiogenic repair in Diabetic Foot Ulcers | #MolecularMedicine #DiabeticFootUlcers #FGF link.springer.com/article/10.1...

Fig. 12 1) Integrated transcriptomic analysis of each microarray and RNA-seq cohort reveals convergent DFU signature with downregulated DEGs enriched for epidermal differentiation, keratinization and extracellular matrix organization gene ontology terms; 2) Gene set variation analysis (GSVA) and Protein–protein interaction networks (PPIN) indicated FGF/FGFR network components are downregulated in DFU; 3) Weighted gene co-expression network analysis (WGCNA) showed a module associated with inflammatory activation positively correlated with DFU status in the microarray cohort, while FGF/FGFR signaling modules were negatively correlated with DFU status in the RNA-seq cohort, Cell-type enrichment analysis revealed reduced stromal and reparative cell populations in the wound microenvironment.; 4) DFU diagnostic model tested and validated across microarray and RNA-seq cohorts identified nine marker genes in a random forest classifier. Among commonly up-regulated DEGs, SERPINE1 was highlig...