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@nicolocovelli.bsky.socialOct 12, 2026, 10:01 AM

Although these approaches need further research and validation, they offer new strategies to treat cancers in a safe and efficient way.

πŸ‘‰οΈ Read more: themolecularcode.substack.com/p/from-whale...

#CancerBiology #MolecularBiology #DNARepair #SciComm

@nicolocovelli.bsky.socialOct 9, 2026, 10:01 AM

Whales, on the other hand, have an enhanced capacity to repair DNA lesions before they become permanent mutations in the genome. This is made possible by the overexpression of CIRBP.

πŸ‘‰οΈ Read more: themolecularcode.substack.com/p/from-whale...
#CancerBiology #MolecularBiology #DNARepair #SciComm

@tenuretracker.bsky.socialOct 9, 2026, 1:58 AM

University of Cambridge (@cam.ac.uk) is hiring:
Post-Doctoral Scientist in Drug Resistance Mechanisms in Paediatric Cancers

#postdoc #medicine #cancerbiology

@beilstein-institut.bsky.socialOct 8, 2026, 8:03 AM

βŒ› Starting soon! There's still time to register for free and hear James Paulson of The Scripps Research Institute discuss "Targeting the sialic acid axis to enhance immune responses to cancer."
πŸ“… Oct 8, 2026 πŸ•” 5–6 pm CEST
πŸ”— https://tinyurl.com/4m834mzp
#CancerBiology #BeilsteinTalks
@scripps.edu

@bio-protocol.bsky.socialOct 8, 2026, 2:23 AM

Immune-Complex-Based In Vitro Deubiquitination Assay

Work by Florence DΓ΄, Sylvain Meloche and Marc J. Servant at UniversitΓ© de MontrΓ©al.

#LifeSciences #Reproducibility #CancerBiology

@thebabaklab.bsky.socialOct 7, 2026, 7:51 PM

In a new Cell review, Douglas Hanahan revisits one of the most influential frameworks in cancer biology.

Link in the comments πŸ‘‡

#HallmarksOfCancer #CancerResearch #Oncology #TumorMicroenvironment #CancerBiology #PrecisionMedicine

@beilstein-institut.bsky.socialOct 7, 2026, 8:02 AM

Ready for tomorrow's free online #BeilsteinTalk? Register now to hear James Paulson of The Scripps Research Institute discuss "Targeting the sialic acid axis to enhance immune responses to cancer."
πŸ“… Oct 8, 2026 πŸ•” 5–6 pm CEST
πŸ”— https://tinyurl.com/4m834mzp
#CancerBiology #BeilsteinTalks
@scripps.edu

@bio-protocol.bsky.socialOct 6, 2026, 2:20 PM

Check out the latest step-by-step protocols in various #LifeSciences fields.

#BioinformaticsandComputationalBiology #CancerBiology #CellBiology #DevelopmentalBiology #Mechanobiology #PlantScience #StemCell

@beilstein-institut.bsky.socialOct 5, 2026, 1:02 PM

πŸ“’ It's glycotime! You're cordially invited to join our free online #BeilsteinTalk "Targeting the sialic acid axis to enhance immune responses to cancer," with James Paulson of The Scripps Research Institute.
πŸ“… Oct 8, 2026 πŸ•” 5–6 pm CEST
πŸ”— https://tinyurl.com/4m834mzp
#CancerBiology #BeilsteinTalks

@nicolocovelli.bsky.socialOct 5, 2026, 10:01 AM

One explanation is that different species have evolved distinct anti-cancer strategies. Bowhead whales evolved a mechanism that allows them to faithfully repair DNA lesions.

πŸ‘‰οΈ Read more: themolecularcode.substack.com/p/from-whale...

#CancerBiology #MolecularBiology #DNARepair #SciComm

@alicefrolov.bsky.socialOct 2, 2026, 5:01 PM

The Vascular Normalization Window in Anti-VEGF Therapy

I am sharing a figure intended to communicate the transient nature of vascular normalization.

#TumorAngiogenesis #VascularNormalization #AntiVEGF #TumorMicroenvironment #Pericytes #TumorVasculature #AntiangiogenicTherapy #CancerBiology

The Vascular Normalization Window in Anti-VEGF Therapy I am sharing a figure intended to communicate the transient nature of vascular normalization during anti-angiogenic treatment, a concept that continues to shape dosing and combination strategy discussions. I want to emphasize at the outset that the underlying data are simulated; the curves are constructed to reproduce trends reported across the preclinical and clinical literature rather than to present novel measurements. The plot is a temporal contour band plot rendering two opposing envelopes against time following VEGF pathway blockade. The first envelope tracks pericyte coverage of the tumor microvasculature, expressed as fractional NG2/PDGFRΞ²-positive perivascular investment, which rises as VEGF withdrawal reduces the destabilizing pressure on nascent endothelium. The second envelope tracks microvessel density, which declines as immature, poorly perfused vessels regress. The shaded intersection identifies the normalization window, the interval during which pericyte recruitment and basement membrane maturation restore a more physiologically competent vascular phenotype before pruning progresses toward frank hypovascularity. Within this window the figure annotates the functional correlates that motivate combination scheduling: reduced interstitial fluid pressure, attenuated hypoxia, improved oxygen and drug delivery, and partial restoration of endothelial barrier integrity. The band widths encode illustrative uncertainty, reflecting the heterogeneity in window timing and duration observed across tumor models and dosing regimens. The mechanistic argument the figure supports is that therapeutic benefit from normalization is inherently self-limiting. Sustained or excessive VEGF inhibition drives the system past the window into a hypoxic, treatment-resistant state, whereas appropriately timed cytotoxic or immunotherapeutic delivery may exploit the transient perfusion gain.
@nicolocovelli.bsky.socialOct 2, 2026, 10:00 AM

How can bowhead whales live for so long with such a low incidence of cancer?
The answer lies in the overexpression of CIRBP that enhances the cell's ability to repair DNA lesions.

πŸ‘‰οΈ Full story here: themolecularcode.substack.com/p/from-whale...

#CancerBiology #MolecularBiology #DNARepair #SciComm

@beilstein-institut.bsky.socialOct 2, 2026, 8:02 AM

πŸš€ Coming up next week: Join our free online #BeilsteinTalk "Targeting the sialic acid axis to enhance immune responses to cancer," with James Paulson of The Scripps Research Institute.
πŸ“… Oct 8, 2026 πŸ•” 5–6 pm CEST
πŸ”— https://tinyurl.com/4m834mzp
#glycobiology #glycotime #CancerBiology #BeilsteinTalks

@sigtrans-sttt.bsky.socialOct 1, 2026, 7:42 AM

A multitarget strategy may help address #TNBC heterogeneity.

Opti-hTIF1Ξ³ suppresses Ξ²-catenin, TGFΞ² and STAT3 signaling while downregulating CD47 and CXCL5, enhancing #macrophage phagocytosis and #antitumoractivity.
#TumorMicroenvironment #CancerBiology
#STTT #OpenAccess: doi.org/10.1038/s413...

Transcriptional intermediary factor 1 gamma-based multitarget gene therapeutic strategy for triple-negative breast cancer
@beilstein-institut.bsky.socialSep 30, 2026, 1:02 PM

Mark your calendars! πŸ§ͺ Join our free online #BeilsteinTalk "Targeting the sialic acid axis to enhance immune responses to cancer," with James Paulson of The Scripps Research Institute.
πŸ“… Oct 8, 2026 πŸ•” 5–6 pm CEST
πŸ”— https://tinyurl.com/4m834mzp
#glycobiology #glycotime #CancerBiology #BeilsteinTalks

@tenuretracker.bsky.socialSep 30, 2026, 7:59 AM

The Ohio State University is hiring:
Post Doctoral Scholar - Comprehensive Cancer Center

#postdoc #medicine #cancerbiology

@sinclaircri.bsky.socialSep 29, 2026, 7:46 PM

Next up in our @sinclaircri.bsky.social seminar series is Dr. Christopher Nicol, Director of our Cancer Biology & Genetics division. Join us at 4:00 on Oct. 22nd - everyone is welcome!
Qs? Send us an email: [email protected]
#CancerResearch #RectalCancer #CancerBiology

@tenuretracker.bsky.socialSep 27, 2026, 10:12 AM

Institute of Cancer Research is hiring:
Postdoctoral Training Fellow in Genomics and Evolutionary Dynamics

#postdoc #medicine #cancerbiology

@tenuretracker.bsky.socialSep 27, 2026, 10:01 AM

Institute of Cancer Research is hiring:
Postdoctoral Training Fellow - Genomics and Evolutionary Dynamics (Computational)

#postdoc #cancerresearch #cancerbiology

@tenuretracker.bsky.socialSep 26, 2026, 11:27 AM

University of Cambridge (@cam.ac.uk) is hiring:
Postdoctoral Researcher in RNA-DNA Hybrids and Cancer Biology

#postdoc #medicine #cancerbiology

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