@stephanhacker2.bsky.socialInsightful talk by Matthias Gehringer at #CovModDrugDiscov.
He gave great insights into his group's work on making new kinases amenable to covalent drug discovery at cysteine and beyond.
onlinelibrary.wiley.com/doi/10.1002/...
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science #Kinase
@stephanhacker2.bsky.socialWe had an amazing poster session at #CovModDrugDiscov! I learned a lot about new warheads, covalent binder optimization and methods to measure target engagement.
Thank you to all presenters for sharing their amazing science.
#DrugDiscovery #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialInteresting talk by Jonathan Pettinger from GSK at #CovModDrugDiscov.
He talked about the power of direct-to-biology (D2B) approaches for fast SAR studies of #CovalentInhibitors.
#D2B #DirectToBiology #DrugDiscovery #ChemBio #ChemSky #Science
@stephanhacker2.bsky.social#CovModDrugDiscov continues with an interesting talk by Mandy Ferdinand from Cancer Research Horizons.
She talked about methods to characterize covalent hits with a special focus on binding kinetics.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@stephanhacker2.bsky.socialThe Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov is off to a great start with an insightful talk by Matt Bilyard from Roche.
He talked about how they select targets for covalent drug discovery and then find and develop covalent binders.
@stephanhacker2.bsky.socialAnd we are on the way with the Covalent Modulation in Drug Disvovery Conference by @britpharmsoc.bsky.social.
Looking forward to two days filled with cutting-edge covalent drug discovery.
@stephanhacker2.bsky.socialI am looking forward to an exciting meeting.
#CovalentInhibitor #DrugDiscovery #ChemSky #Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes
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@americanpeptidesociety.org
@uwmadisonchem.bsky.socialJoin us for an upcoming CHEMBIO Seminar featuring Professor Jason Gestwicki from the University of California, San Francisco.
We hope you’ll join us!
#UWMadison #UWChemistry #ChemicalBiology #CHEMBIO #ProteinScience #DrugDiscovery #Seminar
@chembiotalks.bsky.socialAfter today's very successful 6th Virtual #ChemBioTalks with more than 250 attendees, we already look ahead.
Block your calendars for the 7th Virtual #ChemBioTalks on September 28th, 2027. We are very happy to have keynotes by Alanna Schepartz and Shankar Balasubramanian.
#ChemBio #ChemSky #Science
@stephanhacker2.bsky.socialHow can enzymes be used for novel chemical transformations?
Michelle Chang (@mchanggroup.bsky.social) gave an inspiring keynote lecture at the @chembiotalks.bsky.social including exciting insights into CH-activation reactions.
www.nature.com/articles/s41...
#ChemBioTalks #ChemBio #ChemSky #Science
@chembiotalks.bsky.socialThe 6th Virtual #ChemBioTalks come to an end with an inspiring keynote lecture by Michelle Chang (@mchanggroup.bsky.social).
She talked about her group's amazing work on using enzymes for synthetic chemistry: "Discovery and engineering of new enzymes for biocatalysis".
@stephanhacker2.bsky.socialFascinating chemistry is needed to make the best fluorophores for single molecule imaging.
At the @chembiotalks.bsky.social, Luke Lavis (@rhodamine110.bsky.social) talked about his group's exciting contributions to this field.
www.nature.com/articles/s41...
#ChemBioTalks #ChemBio #ChemSky #Science
@chembiotalks.bsky.socialGreat talk by Luke Lavis (@rhodamine110.bsky.social) at the 6th Virtual #ChemBioTalks.
He talked about the fascinating chemistry behind chemical fluorophores: "Illuminating biological processes using chemistry".
#ChemBio #ChemSky #AnywhereChem #Science
CC: @chemistryeurope.bsky.social
@stephanhacker2.bsky.socialGreat talk by Tomáš Pluskal (@pluskal-lab.org) at the #ChemBioTalks.
He presented #omics, #bioinformatic and #MachineLearning methods to predict the function of enzymes on the example of terpene synthases.
link.springer.com/article/10.1...
www.biorxiv.org/content/10.1...
#ChemBio #ChemSky #Science
@chembiotalks.bsky.socialInteresting talk by Tomáš Pluskal (@pluskal-lab.org) at the 6th Virtual #ChemBioTalks.
He gave exciting insights into plant natural products and the enzymes that make them: "Decoding the chemical universe of plants"
@chembiotalks.bsky.socialThe Flash Talks were again an absolute highlight of the Virtual #ChemBioTalks.
We heard three exciting talks on DNA nanodevices, protein labeling and degraders for bacterial proteins.
Congratulations again to all speakers for winning our Abstract Challenge.
#ChemBio #ChemSky #AnywhereChem #Science
@stephanhacker2.bsky.socialInteresting Flash Talk by Lars Stevens-Cullinane at the 6th Virtual @chembiotalks.bsky.social.
He presented a metal-dependent degrader strategy to address metallo-β-lactamases in Gram-negative bacteria.
pubs.acs.org/jacsat/artic...
#ChemBioTalks #ChemBio #ChemSky #Science
@stephanhacker2.bsky.socialInteresting Flash Talk by @wahyuwidodo.bsky.social at the 6th Virtual @chembiotalks.bsky.social.
He tagged about the enzymatic tagging of proteins using the ADD technology based on the flavin transferase ApbE.
pubs.acs.org/bcches/artic...
#ChemBioTalks #ChemBio #ChemSky #Science #Protein
@stephanhacker2.bsky.socialInteresting Flash Talk at the 6th Virtual @chembiotalks.bsky.social by Yutong Zhang @zyt0329.bsky.social.
She talked about using #DNA nanodevices to study the pH around lysosomes in living cells.