Luke Lavis

@rhodamine110.bsky.social

Chemist at HHMI's Janelia Research Campus. Passionate about designing, building, and giving away fluorescent dyes to illuminate biological systems. Striving to be positive about all things chemistry (except ChemDraw). ORCID: 0000-0002-0789-6343

@rhodamine110.bsky.social

Cool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...

nature.comSingle-cell synaptome mapping of endogenous protein subpopulations in mammalian brain - Nature CommunicationsSynapses are diverse within a single neuron. Here, the authors present a method for single-cell synaptome imaging of endogenous protein subpopulations in the mouse brain, enabling spatial mapping of s...
@rhodamine110.bsky.social

A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...