A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...

Don't miss this review in our latest issue from Lei Wang, Qiuyue Zhang et al. at China Pharmaceutical University discussing how protein phosphorylation can be modulated by proximity-inducing strategies #medchem

Check it out in full below🔽
doi.org/10.1039/d6md...

Gehringer & Heppner, In Pursuit of Enduring Inactivation: A Perspective on the Development and Study of Irreversible-Covalent Inhibitors. Biochemistry 2026 #biochem #biophys #MedChem #ChemBiol #OpenAccess #chemsky 🧪
doi.org/10.1021/acs....

🔓Check out #OpenAccess research by Bernhard Wünsch & co. @uni-muenster.de in our latest issue synthesising γ-amino alcohols embedded in a 1-benzoxepine scaffold as novel ligands of NMDA receptors with GluN2B subunit #medchem

Read in full on our website👇
doi.org/10.1039/d6md...

Opportunity for medicinal chemist at Isomorphic Labs (Cambridge MA USA) #MedChem #SynChem #ChemJobs #chemsky 🧪
job-boards.greenhouse.io/isomorphicla...

What if a protein that's meant to protect your brain can sometimes go rogue? 🧠

Read more about the Weaver Lab's emerging hypothesis of beta amyloid contributing to #Alzheimers disease, as featured in #UofT magazine:

magazine.utoronto.ca/research-ide...

#DrugDiscovery #MedChem #Dementia

americanpeptidesociety.org/research/lip...

#chemsky #chembio #peptides #medchem #epigenetics #drugdiscovery

⌛There's less than a month left until nominations close for the 2027 @rscmedchem.rsc.org Emerging Investigator Lectureship!

If you know an up-and-coming researcher in drug discovery don't miss the opportunity to nominate them #chemsky #medchem

Full details on how to nominate▶️ rsc.li/md-lectureship

Nice example of ligand-based drug design to discover #PPI inhibitors of "smooth" proteins, e.g. #RAS-RAF, & incorporation of protein NMR to show allosteric binding effects. Next would like to see a Cys selectivity screen and improved affinity. #medchem

www.nature.com/articles/s41...

A most excellent molecule (and chemist) with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...

🔓Be sure to read this #OpenAccess paper by Zihuan Fu & Heather D. Maynard @uclacb.bsky.social in our latest issue describing how alternating iterative exponential growth oligomers serve as a platform for hydrophilic antibody–drug conjugates #medchem #orgchem

Find it in full👇
doi.org/10.1039/d6ob...

🔓Take a look in our latest issue at a paper by Hidetsugu Tabata, Hideaki Natsugari et al. developing atropisomeric 5N-sulfonyl-1,5-benzodiazepin-2-ones with high inhibitory activity against neutrophil elastase #medchem

📍Teikyo University
doi.org/10.1039/d6md...

🎓 Milan Štefek from Radim Nencka’s group has successfully defended his PhD dissertation at the @sciencecharles.bsky.social! 🎓

Congratulations on this significant milestone!

#IOCB #IOCBPrague #PhDjourney #PhDatIOCB #medChem #virology #science

🔓Be sure to read #OpenAccess research by Christian Melander & co. from @notredame.bsky.social & @univofmaryland.bsky.social in our latest issue generating sorafenib analogues that exhibit dual Colistin-potentiating and anti-MRSA activity #medchem

Find it in full here🔽
doi.org/10.1039/d6md...

🔓Be sure to read in our latest issue #OpenAccess research from Joseph B. Sweeney & Julien Doulcet @lancasteruni.bsky.social using an aryne–arylamine–aldehyde three-component reaction for the synthesis of drug-like 2-aminobenzyl ethers #orgchem #medchem

Find in full below🔽
doi.org/10.1039/d6ob...

Don't miss the Review behind the inside front cover of our latest issue by Ranjana Pathania et al. from IIT Roorkee discussing AI-enabled discovery of small molecule β-lactamase inhibitors to overcome enzyme diversity and resistance evolution #medchem

doi.org/10.1039/d6md...

A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...

📢Our latest issue is now online!

🔓Check out the #OpenAccess Review behind the cover by Ellen E. Hyde & @andrewbeekman.bsky.social from @uniofeastanglia.bsky.social looking at protein–protein interaction inhibitors in the human proteome #medchem

doi.org/10.1039/d6md...

Moore et al, The rapid emergence of small molecule #RNA modulator hit discovery: unlocking the potential | Expert Opinion on #DrugDiscovery 2026 | #MedChem #DrugDesign #Free2Read #chemsky 🧪 doi.org/10.1080/1746...

🎨 Ready to turn your research into a visual story?
The #GraphicalAbstractCompetition2026 is here! Showcase your science creatively and put your research communication skills to the test. 🧪✨
👉 All details here: qrr.to/f76483b7
#MedChem #ChemBio