What drives synaptic dysfunction in #AutismSpectrumDisorder (ASD)?
This study identifies ADAM10-mediated #Ncadherin cleavage as a potential therapeutic target linked to impaired synaptic plasticity. #ValproicAcid
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

What if #noncodingRNAs encode disease-driving proteins?
This review highlights #exosome-derived ncRNA peptides as promising #biomarkers, therapeutic targets, and next-generation treatments across multiple diseases.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Precision medicine is transforming #cholangiocarcinoma care.
This review highlights advances in targeted therapies and #immunotherapy while addressing challenges such as drug resistance and biomarker discovery. #TumorMicroenvironment
#GenesAndDiseases: doi.org/10.1016/j.ge...

Restoring blood flow can also damage the heart.
This review shows how #inflammasomes drive #IschemiaReperfusionInjury and highlights therapies targeting these inflammatory pathways to improve recovery. @CUHKofficial
#GenesAndDiseases: doi.org/10.1016/j.ge...

Why do some breast cancers spread despite slower tumor growth?
This study identifies mdig as a suppressor of #metastasis in #TripleNegativeBreastCancer, revealing a promising target to limit cancer spread. @stonybrooku.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...

Can disease-causing proteins be eliminated, not just blocked?
This review highlights #PROTAC technology as a promising strategy to target kidney disease drivers and advance precision therapies in #nephrology.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Not all airway #CiliatedCells are alike.
This study maps their diversity, revealing region-specific antioxidant defenses and disease-linked signatures that could guide new therapies for #asthma and #COPD. #RespiratoryDiseases
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Why bone formation fails remains unclear.
This study identifies JAM3 as a key regulator that stabilizes #LRP5, promotes #osteoblast formation, and preserves bone mass, revealing a promising target for skeletal disorders.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Stopping #ThyroidCancer spread starts with understanding its drivers.
This study identifies the ETV4–p300 axis as a key promoter of TGFβ1 signaling and EMT, revealing a promising therapeutic target. #EpithelialMesenchymalTransition
#GenesAndDiseases: doi.org/10.1016/j.ge...

Could one splicing regulator shape #HeartFailure?
This study identifies RBM27 as essential for maintaining Tnnt2 splicing and cardiac function, revealing a promising therapeutic target for heart disease. #AlternativeSplicing
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Cancer cells survive by rewiring metabolism.
This review highlights how #FattyAcidMetabolism fuels #BloodCancer progression and therapy resistance, revealing metabolic vulnerabilities for future precision treatments.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Why do anti-angiogenic therapies fail in #OralCancer?
This study identifies the IL-33/ST2L–TRAF6/NF-κB axis as a driver of #VasculogenicMimicry, revealing TRAF6 inhibition as a strategy to boost bevacizumab efficacy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Why do #EGFR inhibitors stop working?
This single-cell study identifies an HSPA6–FOLR2 macrophage axis that drives osimertinib resistance in #LungCancer, highlighting CCL2 blockade as a promising combination strategy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Reprogramming #TumorMacrophages is a major challenge.
This study shows glutamine inhibition sustains pro-inflammatory M1 macrophages while suppressing #immunosuppressive M2 cells, supporting improved #CancerImmunotherapy. @jhu.edu
#GenesAndDiseases: doi.org/10.1016/j.ge...

Can biological age predict #RetinalDisease?
This review explores how #EpigeneticClocks could reveal aging mechanisms, forecast disease progression, and support precision medicine for age-related eye disorders. @usc.edu
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Is #JAKSTAT a friend or foe in #SolidTumors?
This review reveals paradoxical roles, showing how direct inhibition fuels immune exhaustion and resistance, and proposes system‑level targeting to overcome the impasse.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Microbes can help or hinder cancer therapy.
This review shows how infection and the #microbiome shape #AntitumorImmunity, while highlighting #AI as a tool to improve patient stratification and treatment prediction.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...