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@inflammasomelab.bsky.socialOct 6, 2026, 3:11 AM

Stress hormones don’t just suppress #inflammation, they tune it! Kirsten Kenney and Sabrina Burgener (@s-burgener.bsky.social) review how endogenous #glucocorticoids cross-talk with innate immune signalling, from pattern recognition receptors to #inflammasomes. Open access: doi.org/10.1042/BSR2...

@northwell-journals.bsky.socialSep 10, 2026, 3:40 PM

Molecular Medicine - Journal

Article in Press: Targeting extracellular caspase-1 attenuates sepsis-induced acute lung injury | #MolecularMedicine #eCASP1 #AcuteLungInjury #Sepsis #Inflammasomes
@NorthwellHealth
#FeinsteinInstitutesforMedicalResearch link.springer.com/article/10.1...

Fig. 6 Summary of findings. In sepsis, inflammasomes activation promotes the cleavage of caspase-1 and the extracellular release of its p20 subunit through GSDMD-dependent membrane processes. This release may occur in association with GSDMD pore formation as well as membrane disruption during lytic cell death (pyroptosis). Once released, eCasp-1 acts as a potent DAMP. Therapeutic intervention with the inhibitory peptide C16, which specifically target eCasp-1, effectively attenuates systemic inflammation, ALI, and improves survival outcomes. Acute lung injury, ALI; compound 16, C16; gasdermin-D, GSDMD; extracellular caspase-1, eCasp-1; damage-associated molecular pattern, DAMP
@genesndiseases.bsky.socialSep 9, 2026, 12:30 AM

Restoring blood flow can also damage the heart.
This review shows how #inflammasomes drive #IschemiaReperfusionInjury and highlights therapies targeting these inflammatory pathways to improve recovery. @CUHKofficial
#GenesAndDiseases: doi.org/10.1016/j.ge...

@molneurodegen.bsky.socialSep 8, 2026, 2:55 PM

#Inflammasomes: central mediators of neuroinflammatory #neurodegeneration in #Alzheimers and #Parkinsons disease

Clémence Tropis, Janna Jernigan Posey, Malú Gámez Tansey, @malutansey.bsky.social Michael T. Heneka

link.springer.com/article/10.1...