Scientists Agree: #1 Hair Growth Peptide Ever Invented? #gt20029 #protac #hairgrowth #hairthinning #hairserum #hairpeptides #hairthickening #hairtreatments

A new study in Cell Chemical Biology explored how the mechanism driving oncogene overexpression can determine the effectiveness of protein degraders such as PROTACs.

Link in the comments 👇
#TargetedProteinDegradation #PROTAC #CancerResearch #DrugDiscovery #Oncology

Rather than simply inhibiting #Taspase1, the interdisciplinary team of molecular biologists and synthetic chemistst aims to trigger its targeted degradation using a combination of nanobodies and #PROTAC technology.

This week #JournalClub @labsoap.bsky.social @nature.com #protac #glue #ALK www.nature.com/articles/s41...

Can disease-causing proteins be eliminated, not just blocked?
This review highlights #PROTAC technology as a promising strategy to target kidney disease drivers and advance precision therapies in #nephrology.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Intratumoral microbes may actively shape #Cancer evolution.

In #NSCLC, M. abscessus NDK phosphorylates IRF3 at H263 to sustain APOBEC3A mutagenesis, while NDK inactivation or NDK-#PROTAC treatment suppresses this process.

#STTT #OpenAccess: doi.org/10.1038/s413...

#DrugResistance limits #Androgen-targeted therapy in castration-resistant #ProstateCancer.

A self-assembling nano-#PROTAC degrades AR, AR-V7, and HSP90, suppressing enzalutamide-resistant tumor growth and extending survival in mice.

#STTT #OpenAccess: doi.org/10.1038/s413...