How can next-generation personalized #CancerVaccines overcome #Immunosuppressive microenvironments?

This review evaluates mRNA, DNA, and #Nanovaccine platforms combined with checkpoint inhibitors for durable immunity.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerStemness

TKTL1-driven #Glycolysis increases lactate and promotes #Immunosuppressive dendritic-cell signaling in #HCC. Targeting the TKTL1–HIF-1α–HK2 axis and lactate reprograms the #TumorMicroenvironment to enhance PD-1 blockade.

#STTT #OpenAccess: doi.org/10.1038/s413...

#TumorHeterogeneity and #Immunosuppressive microenvironments hinder the treatment of #SolidTumors.

This review explores diverse immune and stem-cell platforms, alongside allogeneic and in vivo engineering strategies for broader cancer treatment.

#STTT #OpenAccess: doi.org/10.1038/s413...

Reprogramming #TumorMacrophages is a major challenge.
This study shows glutamine inhibition sustains pro-inflammatory M1 macrophages while suppressing #immunosuppressive M2 cells, supporting improved #CancerImmunotherapy. @jhu.edu
#GenesAndDiseases: doi.org/10.1016/j.ge...