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@sigtrans-sttt.bsky.socialSep 23, 2026, 6:30 AM

#HSP90 promotes ROC1 stability in #LungAdenocarcinoma by shielding it from CHIP-mediated #Ubiquitination and degradation. HSP90 inhibition restores ROC1 destabilization and suppresses #tumor growth, defining an HSP90–CHIP–ROC1 axis.

#STTT #OpenAccess: doi.org/10.1038/s413...
#ClinicalTrials

HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma
@sigtrans-sttt.bsky.socialSep 13, 2026, 6:30 AM

Metastatic organotropism shapes #LungAdenocarcinoma progression.
This study identifies tumor, immune and stromal signatures associated with organ-specific #Metastasis, highlighting #Biomarkers and #TherapeuticTargets.

#STTT #OpenAccess: doi.org/10.1038/s413...

Mechanisms and therapeutic targets in distant metastasis of lung adenocarcinoma