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@northwell-journals.bsky.socialSep 10, 2026, 3:55 PM

Molecular Medicine - Journal
Article in Press: Endoplasmic reticulum stress-mediated PPARα-DDX3X interaction promotes immune-induced liver injury | #MolecularMedicine #PPAR #EndoplasmicReticulum #ImmuneSystem #LiverInjury

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@northwell-journals.bsky.socialSep 10, 2026, 3:53 PM

Molecular Medicine - Journal
Article in Press: Transmembrane glycoprotein GPNMB is a candidate predictive biomarker and target in metastatic renal cell carcinoma | #MolecularMedicine #Biomarkers #RenalCellCarcinoma #mRCC link.springer.com/article/10.1...

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@northwell-journals.bsky.socialSep 10, 2026, 3:52 PM

Molecular Medicine - Journal
Article in Press: Recent advances in delivery strategies for CRISPR-based genome editing | #MolecularMedicine #CRISPR #GenomeEditing link.springer.com/article/10.1...

Fig. 2 Multiple strategies for CRISPR delivery. A Clinical CRISPR-based genome editing can be accomplished by either in vivo or ex vivo delivery strategies. The ex vivo strategy entails the extraction of target cells from the patient, followed by precision genome editing within a controlled biomanufacturing environment, and concludes with the reinfusion or engraftment of the modified cells. Conversely, the in vivo strategy involves the direct administration of the CRISPR machinery into the patient, requiring the diverse delivery methods to successfully navigate physiological barriers to reach the designated tissues. B Four primary categories of vectors utilized for the intracellular CRISPR delivery. Viral vectors leverage the highly evolved infectious pathways of viruses, such as adenovirus, adeno-associated virus, and lentivirus. Physical methods actively induce transient cellular porosity, encompassing microinjection and electroporation. Nanoparticle-based methods, provide high....
@northwell-journals.bsky.socialSep 10, 2026, 3:51 PM

Molecular Medicine - Journal
Article in Press: Clinical transcriptomics towards a companion diagnostic framework for immunotherapy in cutaneous melanoma | #MolecularMedicine #Immunotherapy #Melanoma #Transcriptomics link.springer.com/article/10.1...

Fig. 1 A Graphical Abstract representing the process of pre-treatment biopsies transcriptomics dataset extraction. B Sankey plot summarizing the assembled dataset used for analysis and modelling, depicting origin dataset, RECIST response levels (original and collapsed into three classes), and binary response
@northwell-journals.bsky.socialSep 10, 2026, 3:50 PM

Molecular Medicine-Journal
Article in Press: The nutrition–microbiota–gut–kidney axis in acute kidney injury: molecular mechanisms, candidate biomarkers, and investigational intervention strategies #MolecularMedicine #Nutrition #GutMicrobiota #AcuteKidneyInjury link.springer.com/article/10.1...

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@northwell-journals.bsky.socialSep 10, 2026, 3:46 PM

Molecular Medicine - Journal

Article in Press: Stem cell–derived islet replacement therapies for diabetes: current progress and translational challenges | #MolecularMedicine #Diabetes #StemCells #transplantation link.springer.com/article/10.1...

Fig. 2 Schematic representation of in vivo pancreatic organogenesis and in vitro SC-islet differentiation. A In vivo pancreatic development. Beginning from the pluripotent blastocyst stage, cells undergo gastrulation to form the definitive endoderm, which subsequently forms the primitive gut tube. Pancreatic buds emerge from the posterior foregut comprising multipotent pancreatic progenitor cells. The epithelium then expands and segregates into tip and trunk domains. Tip cells give rise to acinar progenitors, whereas ductal and endocrine progenitors arise from trunk. Endocrine progenitors differentiate into all endocrine pancreatic lineages that constitute the islets of Langerhans. B In vitro differentiation of SC-islets. Differentiation protocols recapitulate key steps of in vivo development. Through the sequential addition of signaling pathway activators and inhibitors (red), pluripotent stem cells are guided through successive progenitor stages towards functional islet-like clusters
@northwell-journals.bsky.socialSep 10, 2026, 3:43 PM

Molecular Medicine - Journal

Article in Press: Three decades of ischemic heart disease–related heart failure in G20 countries: shifting burden, inequalities, and projections to 2050 | #MolecularMedicine #IschemicHeartDisease #HeartFailure #G20 #HealthInequality link.springer.com/article/10.1...

Fig. 1 ASPRs of IHD-related HF burden among G20 coun tries in 1990 (A), in 2021 (B) and during 1990 to 2021 (C). ASPRs indicates age-standardized prevalence rates; G20, Group of 20 (countries); HF, heart failure; and IHD, ischemic heart disease. ASPR, Age-Standardized Prevalence Rate; EAPC, Estimated Annual Percentage Change
@northwell-journals.bsky.socialSep 10, 2026, 3:42 PM

Molecular Medicine - Journal

Article in Press: Glucose-dependent regulation of hepatic adipsin controls glucose uptake and tolerance | #MolecularMedicine #Glucose #Adipsin #Hepatocytes #Liver #Diabetes #MASLD link.springer.com/article/10.1...

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@northwell-journals.bsky.socialSep 10, 2026, 3:41 PM

Molecular Medicine - Journal
Article in Press: Longitudinal profiling of urinary extracellular vesicle RNA reveals physiological variability and stable reference genes in healthy individuals | #MolecularMedicine #ExtracellularVesicles #RNA #Biomarkers #CIBERSORT link.springer.com/article/10.1...

Fig. 2 Comprehensive overview of the RNA profile in uEVs. A Flowchart illustrating the sampling procedure for RNA sequencing of uEVs. B Sankey diagram illustrates the distribution of 30 RNA-Seq samples from 12 donors, including four longitudinal sampling time points and sex distribution. D1, D15, D29, and D43 indicate sampling days 1, 15, 29, and 43, respectively. C Number of expressed protein-coding genes and lncRNAs detected in each sample (raw count ≥ 1). The first two digits of the sample ID represent the sampling time point, and the last two digits indicate the donor ID.
@northwell-journals.bsky.socialSep 10, 2026, 3:40 PM

Molecular Medicine - Journal

Article in Press: Targeting extracellular caspase-1 attenuates sepsis-induced acute lung injury | #MolecularMedicine #eCASP1 #AcuteLungInjury #Sepsis #Inflammasomes
@NorthwellHealth
#FeinsteinInstitutesforMedicalResearch link.springer.com/article/10.1...

Fig. 6 Summary of findings. In sepsis, inflammasomes activation promotes the cleavage of caspase-1 and the extracellular release of its p20 subunit through GSDMD-dependent membrane processes. This release may occur in association with GSDMD pore formation as well as membrane disruption during lytic cell death (pyroptosis). Once released, eCasp-1 acts as a potent DAMP. Therapeutic intervention with the inhibitory peptide C16, which specifically target eCasp-1, effectively attenuates systemic inflammation, ALI, and improves survival outcomes. Acute lung injury, ALI; compound 16, C16; gasdermin-D, GSDMD; extracellular caspase-1, eCasp-1; damage-associated molecular pattern, DAMP
@northwell-journals.bsky.socialSep 10, 2026, 3:38 PM

Molecular Medicine - Journal

Article in Press: HEATR1 deficiency enhanced gastric cancer cell PANoptosis to boost anti-tumor immunity | #MolecularMedicine #GastricCancer #PANoptosis #HEATR1 #ImmuneCheckpointInhibitor link.springer.com/article/10.1...

Fig. 6 HEATR1 knockdown PDOs were prone to PANoptosis and enhanced DC-primed CD8+ T cell expansion. A PDOs and PMBC-derived CD8+ T cells and immature DCs were obtained from the same patient. After pulsing with PDO supernatants, mature DCs were cocultured with CD8+ T cells.
@northwell-journals.bsky.socialSep 10, 2026, 3:37 PM

Molecular Medicine - Journal
Article in Press: Research advances on CD47 in digestive system cancers: from molecular mechanisms to clinical translation #MolecularMedicine #CD47 #Cancer #DigestiveSystem link.springer.com/article/10.1...

Fig. 1 Upstream regulation of CD47 and the CD47–SIRPα signaling axis in digestive system cancers. A Examples of CD47 regulation in digestive system cancers include Galectin-3 in gastric cancer, the LINC00460/miR-186-3p/MYC network in colorectal cancer, and miR-133a in esophageal cancer. B CD47 binding to SIRPα induces ITIM phosphorylation and recruits SHP-1/2, thereby inhibiting macrophage phagocytosis. Reduced recruitment and activation of non-muscle myosin IIA is one downstream effect. C CD47 blockade can increase macrophage-mediated tumor-cell phagocytosis. Tumor-antigen uptake and MHC class I cross-presentation by dendritic cells may also promote CD8 + T-cell priming.
@dgfi-yi.bsky.socialSep 9, 2026, 12:02 PM

📢 Considering attending the #CMMCSymposium2026?

✅ Abstract deadline extended to 14 Sept 2026
✅ New speaker: Dr. Arvid Sandforth (Charité Berlin)

A great opportunity for early-career researchers to present their work and network in Cologne!

#MolecularMedicine #Metabolism

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