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@northwell-journals.bsky.social Sep 10, 2026, 3:37 PM

Molecular Medicine - Journal
Article in Press: Research advances on CD47 in digestive system cancers: from molecular mechanisms to clinical translation #MolecularMedicine #CD47 #Cancer #DigestiveSystem link.springer.com/article/10.1...

Fig. 1 Upstream regulation of CD47 and the CD47–SIRPα signaling axis in digestive system cancers. A Examples of CD47 regulation in digestive system cancers include Galectin-3 in gastric cancer, the LINC00460/miR-186-3p/MYC network in colorectal cancer, and miR-133a in esophageal cancer. B CD47 binding to SIRPα induces ITIM phosphorylation and recruits SHP-1/2, thereby inhibiting macrophage phagocytosis. Reduced recruitment and activation of non-muscle myosin IIA is one downstream effect. C CD47 blockade can increase macrophage-mediated tumor-cell phagocytosis. Tumor-antigen uptake and MHC class I cross-presentation by dendritic cells may also promote CD8 + T-cell priming.

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