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@northwell-journals.bsky.social Sep 10, 2026, 3:40 PM

Molecular Medicine - Journal

Article in Press: Targeting extracellular caspase-1 attenuates sepsis-induced acute lung injury | #MolecularMedicine #eCASP1 #AcuteLungInjury #Sepsis #Inflammasomes
@NorthwellHealth
#FeinsteinInstitutesforMedicalResearch link.springer.com/article/10.1...

Fig. 6 Summary of findings. In sepsis, inflammasomes activation promotes the cleavage of caspase-1 and the extracellular release of its p20 subunit through GSDMD-dependent membrane processes. This release may occur in association with GSDMD pore formation as well as membrane disruption during lytic cell death (pyroptosis). Once released, eCasp-1 acts as a potent DAMP. Therapeutic intervention
with the inhibitory peptide C16, which specifically target
eCasp-1, effectively attenuates systemic inflammation, ALI,
and improves survival outcomes. Acute lung injury, ALI;
compound 16, C16; gasdermin-D, GSDMD; extracellular
caspase-1, eCasp-1; damage-associated molecular pattern,
DAMP

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