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JAMA Neurology

@jamaneurology.com

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JAMA Neurology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.

🌐 JAMANeurology.com

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@jamaneurology.comOct 10, 2026, 3:00 PM

Among patients with relapsing #MultipleSclerosis, earlier and continuous ocrelizumab treatment was associated with better long-term relapse and disability control than delayed initiation after interferon beta-1a.

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JAMA Neurology RCT on Ocrelizumab for Relapsing MS over 10 years. 1656 patients (563M, 1093F, mean age 37). Ocrelizumab group (82.2%) showed greater freedom from 48-wk confirmed disability progression than Interferon beta-1a group (79.9%), HR 0.76.
@jamaneurology.comOct 10, 2026, 12:00 PM

Among pediatric inpatients with unexplained #Neurologic presentations, rapid #WholeGenomeSequencing diagnosed nearly half of patients and changed management in about 2-thirds of diagnosed cases.

ja.ma/4eqxDXI

Horizontal bar chart compares Phenotype-concordant (gray) vs. No concordant (orange) diagnosis across patient features. Key findings: Neonates' Hypotonia shows 30/33 patients concordant (P<.001); Nonneonates' Development delay 36/49 (P=.002); Pooled Multisystem involvement 51/82 (P=.01).
@jamaneurology.comOct 6, 2026, 6:00 PM

Among patients with relapsing #MultipleSclerosis, earlier and continuous ocrelizumab treatment was associated with better long-term relapse and disability control than delayed initiation after interferon beta-1a.

ja.ma/4yuFhZ7

JAMA Neurology RCT on Ocrelizumab for Relapsing MS over 10 years. 1656 patients (563M, 1093F, mean age 37). Ocrelizumab group (82.2%) showed greater freedom from 48-wk confirmed disability progression than Interferon beta-1a group (79.9%), HR 0.76.
@jamaneurology.comOct 6, 2026, 5:00 PM

Among patients evaluated for cognitive symptoms, earlier disclosure of blood-based biomarkers increased diagnostic certainty without worsening anxiety, depressive symptoms, perceived stress, or quality of life.

ja.ma/4jcYyK5

JAMA Neurology RCT: Earlier Disclosure of Blood-Based Biomarkers, Diagnostic Certainty, and Clinical Management. Study of 220 adults (median 73) in Spain shows earlier disclosure of AD biomarkers increased high-confidence diagnoses. Graph compares certainty levels over 3 visits for early vs. delayed disclosure groups.
@jamaneurology.comOct 6, 2026, 4:30 PM

💬 Editorial: In children with #NeurologicDisease, rapid #WholeGenomeSequencing may support earlier diagnosis and management changes, with increasing relevance as precision therapies emerge.

ja.ma/4ASKaN8

JAMA Neurology editorial: "Whole Genomes, Clearer Diagnoses—Precision Care for Children With Neurologic Disease" by Terrie E. Inder, MBChB, MD. Published Online: October 5, 2026. DOI: 10.1001/jamaneurol.2026.3008.
@jamaneurology.comOct 6, 2026, 4:27 PM

Among pediatric inpatients with unexplained #Neurologic presentations, rapid #WholeGenomeSequencing diagnosed nearly half of patients and changed management in about 2-thirds of diagnosed cases.

ja.ma/4AYIvWH

Horizontal bar chart compares Phenotype-concordant (gray) vs. No concordant (orange) diagnosis across patient features. Key findings: Neonates' Hypotonia shows 30/33 patients concordant (P<.001); Nonneonates' Development delay 36/49 (P=.002); Pooled Multisystem involvement 51/82 (P=.01).
@jamaneurology.comOct 1, 2026, 1:00 PM

Can anesthesia choice during #stroketreatment affect recovery?
#sedation #anesthesia

📌 Learn more: ja.ma/4hHLMll

@jamaneurology.comSep 29, 2026, 1:00 PM

In #MOGAD, MRI lesions often resolve over time and asymptomatic radiological activity is rare, limiting the clinical utility of surveillance MRI compared with multiple sclerosis.

ja.ma/4ykzTrn

@jamaneurology.comSep 28, 2026, 4:00 PM

💬 Viewpoint: The role of #LeftAtrialAppendageClosure in #AtrialFibrillation may depend on patient phenotype, and more evidence is needed in patients who cannot take long-term direct oral anticoagulants. ja.ma/3TUWgVv

@jamaneurology.comSep 28, 2026, 3:30 PM

Among older adults with #MildCognitiveImpairment and hearing loss, hearing aid intervention did not significantly reduce dementia-level impairment over 24 months vs hearing care education. ja.ma/4yWDzzB

@jamaneurology.comSep 22, 2026, 2:00 PM

🧠 Portable low-field #MRI of the brain showed strong agreement with conventional MRI for key volumetric measures and may expand access to brain health assessment outside traditional radiology settings. ja.ma/3V77fvh

@jamaneurology.comSep 22, 2026, 12:00 PM

This case report describes 11.7-T in vivo human brain magnetic resonance imaging (MRI) of the basal ganglia in 2 healthy volunteers. ja.ma/4y89Tzq

@jamaneurology.comSep 21, 2026, 4:00 PM

📝 The #HINTS examination is most effective in patients with continuous dizziness and spontaneous nystagmus at rest.

This Review indicates that outside this population , HINTS can reduce stroke diagnostic accuracy and lead to unnecessary imaging.

ja.ma/4xDD7VV

Clinical decision algorithm for acute-onset persistent dizziness. It screens for central features, then horizontal nystagmus at rest, and assesses gait. Key outcomes are workup for acute stroke, peripheral cause (vestibular neuritis), or HINTS suggesting central cause.
@jamaneurology.comSep 21, 2026, 3:30 PM

📊🧠 A harmonized #TauPET visual reading framework for #AlzheimerDisease with five classes showed high agreement across raters and tracers, and identified more early-stage tau pathology than the regulatory-approved binary approach.

ja.ma/4hiNHLV

Brain anatomy with multi-colored masks in superior, inferior, lateral, and medial views. A table shows Harmonized tau PET visual read classification criteria from Negative to Atypical. Three PET brain scans (Sagittal, Coronal, Axial) display brain activity using a red-blue-green color scale.
@jamaneurology.comSep 14, 2026, 6:39 PM

📝 #Review from @jama.com: #Idiopathic normal pressure hydrocephalus is a progressive neurologic disorder in older adults associated with gait impairment and often urinary dysfunction and cognitive decline.

🔗 Learn more: ja.ma/3Tuhut6

Diagram illustrating Idiopathic Normal Pressure Hydrocephalus (iNPH) pathophysiology from JAMA. It details mechanisms like altered CSF dynamics, increased pulsatility, elevated venous pressure reducing CSF drainage, and CSF accumulation causing ventriculomegaly and brain compression.
@jamaneurology.comSep 6, 2026, 2:33 PM

Among patients with #BranchAtheromatousDisease-related #IschemicStroke, intravenous #Tirofiban plus aspirin did not reduce early neurological deterioration or new stroke compared with aspirin alone.

ja.ma/4cYrWQ8

JAMA Neurology RCT on Tirofiban+aspirin vs. placebo+aspirin for stroke. 970 patients (607M, 363F, median 63y) in China. Findings: No significant difference in early neurological deterioration or new stroke incidence between groups. Graph shows similar cumulative incidence for both (HR 0.88, P=.39).
@jamaneurology.comSep 6, 2026, 2:30 PM

💬 Editorial: Among patients with #BranchAtheromatousDisease-related #IschemicStroke, the trial did not show an overall benefit of tirofiban plus aspirin.

ja.ma/3UDTDrh

JAMA Neurology Editorial: 'Tirofiban for Branch Atheromatous Disease—End of the Line or New Opportunity?' authored by Dixon Yang, S. Andrew Josephson, and Hooman Kamel. Published online August 31, 2026.
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