🔖 JAMA+ Trials is a new platform that highlights the implications and innovations of #ClinicalTrial research from across the JAMA Network to advance evidence-based #medicine and public #health.

📬 Learn more and subscribe to the email newsletter: jamanetwork.com/channels/tri...

🔖 This October's Trial Theme of the Month focuses on extension studies in #ClinicalTrials, where long-term findings depend on how comparison groups are defined and how attrition and selection bias are handled.

🔗 Read the latest editorial: ja.ma/4zqdoBD

Among working-age adults in the US, #HeatRelated mortality varied substantially by occupation and industry, with the highest rates in military, farming, fishing and forestry, and construction and extraction occupations.

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💬 Editorial: Among older adults with serious illness, both facilitated and self-guided #AdvanceCarePlanning approaches were associated with high rates of advance care planning completion, with no significant differences within Black or White groups.

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Among Black and White older adults with serious illness, a facilitated #AdvanceCarePlanning approach did not result in significantly different 1-year advance care planning completion than a self-guided approach within either racial group. ja.ma/3VzXINF

💬 Editorial: In #ClinicalTrials, extension studies that rely on external controls, simulated comparators, or crossover designs can add useful long-term outcome data, but each approach introduces trade-offs in internal validity and interpretability.

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In urban Cienfuegos, Cuba, population control of #Hypertension increased substantially between 2011 and 2023, with improvements in awareness, treatment, and control among treated individuals.

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To align with the 2027 International Women’s Day, JAMA and the JAMA Network journals will publish women’s health articles across the full spectrum of health care on March 8, 2027.

🔗 Learn more in this editorial: ja.ma/3Wd2fFQ

💬 Editorial: #WomensHealth extends beyond #reproductive #health, #pregnancy, #menopause, and breast and #gynecologic #cancer, and sex differences affect many conditions across medicine. ja.ma/3Wd2fFQ

#HealthyDialogue: Approximately 1 in 5 Americans live in rural areas, and upcoming changes under the One Big Beautiful Bill Act may substantially reshape their health care options.

🎙️ Learn more in this episode of Healthy Dialogue: ja.ma/47FAatj

💬 Viewpoint by Emily Packard Dawson, PhD, and Lainie Friedman Ross, MD, PhD: In #Genetics and genomics, germline gene editing raises distinct ethical concerns because intended and unintended edits would extend beyond the treated embryo to future generations. ja.ma/3VSVuJd

📊 Research Summary: For early #ParkinsonDisease, nicotinamide riboside did not support disease modification, and nonmotor symptom burden worsened more than with placebo.

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Among patients with early #ParkinsonDisease, treatment with nicotinamide riboside for 52 weeks did not improve clinical outcomes vs placebo and was associated with worse change in overall Movement Disorder Society Unified Parkinson Disease Rating Scale scores. ja.ma/4e4z3af

From 2010 to 2025, US acute care hospital closures exceeded openings, resulting in a net loss of hospitals and hospital beds.

Closure rates were similar in urban and rural areas, while smaller, for-profit, and safety net hospitals closed more often.

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#MedNews: Unapproved #GLP-1 drugs such as retatrutide and zenagamtide are being sold on the black market, raising concerns about questionable quality and safety issues.

#MedNews: As daily alcohol use declines among younger adults, routine #cannabis use is rising.

What are the risks of more frequent use? Read more:

Nearly 2 million pediatric concussions occur in the US each year. In the first 24 to 72 hours after a potential head injury, a comprehensive concussion assessment can help identify important signs and symptoms in children and adolescents.

📌 Learn more: ja.ma/4yrjOR3