The Lancet Diabetes & Endocrinology

@thelancetendo.bsky.social

Your leading source of international, cutting-edge research, review, and opinion in clinical #diabetes and #endocrinology. IF=36·3.

🌐 thelancet.com/journals/landia/home

@thelancetendo.bsky.social Oct 11, 2026, 1:40 PM

Since its first description by Thomas Addison in 1855, dramatic advancements have been made in the management of #Addison's disease, transforming it from a predominantly lethal disease to a manageable condition with in most cases expected long-term survival
www.thelancet.com/journals/lan...
#EndoSky

@thelancetendo.bsky.social Oct 11, 2026, 11:58 AM

Reduced appetite, rapid weight loss, gastrointestinal adverse effects, & changes in eating behaviour might create nutritional, functional, or psychological risks in some individuals taking #incretin-based therapies www.thelancet.com/journals/lan...
#weightloss
#FREE w/reg

#MedSky #EndoSky #PsychSky

@thelancetendo.bsky.social Oct 11, 2026, 11:53 AM

Within the past 15 years, multiple drugs with different administration forms, mechanisms of action, & weight-loss efficacy have been approved by the US FDA or European Medicines Agency for the treatment of #obesity & obesity-related complications www.thelancet.com/journals/lan...
#weightloss

@thelancetendo.bsky.social Oct 11, 2026, 10:21 AM

Read more about the evolution of novel pharmacological approaches for lipid lowering during the first quarter of the 21st century
thelancet.com/journals/lan...
#LDL #cholesterol #cardiovascular #disease #prevention

#MedSky #EndoSky #CardioSky

A transition from daily oral small molecules to long-acting biologic and nucleic acid-based therapies, including monoclonal antibodies, RNA-targeted agents, immunisation strategies, and gene-editing technologies, delivered subcutaneously or intravenously at extended intervals. Despite this temporal representation, new small molecules and other oral therapies continue to be actively developed, reflecting ongoing innovation across both oral and long-acting treatment platforms.

@thelancetendo.bsky.social Oct 11, 2026, 10:21 AM

#Cholesterol-lowering medicine has changed almost beyond recognition over the past 25 years—from early #statin trials to today's longer-acting, less frequently dosed therapies, some of which may eventually require only one or two doses a year youtube.com/watch?v=atCH...
#LDL #CVD
#MedSky #CardioSky

@thelancetendo.bsky.social Oct 11, 2026, 9:25 AM

#Familial #hypercholesterolaemia is an autosomal, semi-dominant condition characterised by markedly elevated plasma #LDL #cholesterol concentration from birth, xanthomas, & early onset of #atherosclerotic #cardiovascular disease (#ASCVD) thelancet.com/journals/lan...
#HeFH #HoFH

#EndoSky #CardioSky

Previous manifestations of ASCVD, especially myocardial infarction and an elevated coronary plaque burden on cardiac CT, indicate a higher risk for ASCVD events. The risk depends not only on very high LDL cholesterol concentrations or exposure to elevated LDL cholesterol during lifetime, but also on the presence or risk biomarkers like male sex, high lipoprotein(a), low HDL cholesterol, high BMI and blood pressure, family history of early ASCVD, smoking and comorbidities like diabetes and chronic kidney disease. Specific familial hypercholesterolaemia risk equations, such as SAFEHEART-RE and the familial hypercholesterolaemia risk score, can integrate this risk. ASCVD risk might also be modulated by the effect of genes unrelated to lipids, as aggregated in a polygenic risk score. LDL cholesterol should always be reduced in patients with familial hypercholesterolaemia. Severe familial hypercholesterolaemia is a clear indication for more intensive LDL cholesterol lowering with PCSK9 inhibitors. ASCVD=atherosclerotic cardiovascular disease.

@thelancetendo.bsky.social Oct 10, 2026, 12:02 PM

Health-care practitioners need to be aware that #emotional problems are common in #diabetes & often overlooked & follow guidelines that recommend assessing these problems, providing mental health care if needed www.thelancet.com/journals/lan...
#T1D #T2D #GDM #mentalhealth

#EndoSky #PsychSky

@thelancetendo.bsky.social Oct 10, 2026, 11:53 AM

Further research is needed to identify the determinants of #survival and #healthy #ageing among people with type 1 #diabetes, including potential differences between youth-onset and adult-onset disease www.thelancet.com/journals/lan...
#T1D #olderadults #aging

#MedSky #EndoSky

@thelancetendo.bsky.social Oct 10, 2026, 11:42 AM

Increasing evidence indicates that #progression & #complications [of type 2 #diabetes] might be modifiable, but the absence of a core outcome set for disease modification limits trial design & intervention comparison www.thelancet.com/journals/lan...
#disease-modifying therapies

#MedSky #EndoSky

@thelancetendo.bsky.social Oct 10, 2026, 11:35 AM

The global prevalence of #diabetes is rising rapidly, with the steepest increases and greatest unmet need occurring in low-income and middle-income countries.

Read more in this global perspective on the role of #primary #care www.thelancet.com/journals/lan... #T2D #LMICs

#MedSky #EndoSky

@thelancetendo.bsky.social Oct 9, 2026, 1:15 PM

The pathophysiology of #Hashimoto's #thyroiditis involves an interplay of genetic susceptibility, environmental exposures, & epigenetic modifications that disrupt immune tolerance, promoting T-cell mediated thyroid injury & thyroid autoantibody production
www.thelancet.com/journals/lan...

#EndoSky

@thelancetendo.bsky.social Oct 9, 2026, 8:11 AM

Sten Madsbad & Jens J Holst comment on:
#Petrelintide and the evolving role of #amylin agonism in #obesity thelancet.com/journals/lan...
#FREE to read w/reg (also FREE)

#MedSky #EndoSky

@thelancetendo.bsky.social Oct 9, 2026, 8:11 AM

#Petrelintide is a novel, long-acting #amylin analogue being developed for long-term treatment of #obesity, leveraging a mechanism of action distinct from incretin-based treatments thelancet.com/journals/lan...
#FREE to read w/reg (also FREE)

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@thelancetendo.bsky.social Oct 9, 2026, 7:08 AM

Shukri F Mohameda & Andre Pascal Kengne comment on:
What #Mauritius teaches us about #diabetes #surveillance thelancet.com/journals/lan...
#T2D #prevalence #OGTT
#FREE to read w/reg (also FREE)

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@thelancetendo.bsky.social Oct 9, 2026, 7:08 AM

#Mauritius is the first country to show a decreasing prevalence of type 2 #diabetes and intermediate hyperglycaemia over time, using the objective, gold standard #OGTT-based diagnostic criteria recommended by the WHO thelancet.com/journals/lan...
#FREE to read w/reg (also FREE)

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@ebiomedicine.bsky.social Oct 8, 2026, 9:29 AMReposted by @thelancetendo.bsky.social

Single-cell analysis of human ovarian tissue reveals unexpected susceptibility of ovarian glial cells to phthalate exposure. The findings advance understanding of chemical risks to women's reproductive health and fertility. @ki.se
#WomensHealth #Fertility #EnvironmentalHealth
Open Access 🔗 below!

@thelancetendo.bsky.social Oct 9, 2026, 6:21 AM

Published in @ebiomedicine.bsky.social

A proteome-based classification of paediatric #adrenocortical #tumours links functional tumour states to clinical outcome and therapeutic vulnerabilities www.thelancet.com/journals/ebi...
#OpenAccess

#MedSky #EndoSky

@thelancetendo.bsky.social Oct 8, 2026, 5:29 PM

Diagnosis of #Hashimoto's #thyroiditis is based on integrating clinical features, #thyroid function tests, thyroid antibody assessment, and characteristic imaging findings thelancet.com/journals/lan...
primary #hypothyroidism

#MedSky #EndoSky

@lancetgastrohep.bsky.social Oct 8, 2026, 8:57 AMReposted by @thelancetendo.bsky.social

Our November 2026 issue is out now - visit www.thelancet.com/gastrohep!

Content includes: #IBD, #MASH, #livercancer, #colorectalcancer, #cirrhosis, #IBS + more...

#GastroSky #MedSky #LiverSky #IBDSky #OncSky

@thelancetendo.bsky.social Oct 8, 2026, 10:17 AM

Turner syndrome is a sex chromosome abnormality in female individuals characterised by the complete or partial loss of one X chromosome in all or some cells www.thelancet.com/journals/lan...
#Turner syndrome

#MedSky #EndoSky

Traditional genotype–phenotype models of Turner syndrome emphasise haploinsufficiency of individual X-linked genes. However, emerging genomic, epigenomic, transcriptomic, proteomic, and metabolomic data suggest that loss of sex-chromosome dosage produces genome-wide regulatory effects. Loss of Xp, PAR1, and X-inactivation escape genes could perturb epigenetic regulators, transcriptional networks, immune pathways, and metabolic signalling. These disturbances propagate across autosomal gene networks and manifest in a tissue-specific manner, contributing to cardiovascular, skeletal, ovarian, metabolic, immune, neurocognitive, and ageing-related features of Turner syndrome. This network model could help explain the limited genotype–phenotype correlation and the marked clinical variability observed even among individuals with 45,X monosomy.

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