@danielhurdiss.bsky.social
Assistant Professor at Utrecht University π³π±
We use #cryoEM and molecular #virology techniques to study the infection mechanisms of +ssRNA viruses.
https://www.uu.nl/medewerkers/DLHurdiss
Views are my own.
@haselbachlab.bsky.socialReposted by @danielhurdiss.bsky.socialI am so proud of this achievement for Sascha. If you want to know about his amazing work that led to this award check out his two preprints: www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
@danielhurdiss.bsky.socialTowards broader-spectrum direct-acting antivirals against RNA viruses
@sjorsscheres.bsky.socialReposted by @danielhurdiss.bsky.socialWe have 2 new preprints on @biorxivpreprint.bsky.social that describe reconstitution of #Alzheimers paired helical filaments in experimental model systems: one in human brain organoids and one in murine primary cultures.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
@nobelprize.orgReposted by @danielhurdiss.bsky.socialBREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel βfor their discoveries concerning light-gated ion channels and optogenetics.β
@danielhurdiss.bsky.socialMechanism of spike opening in a mammalian gammacoronavirus
@danielhurdiss.bsky.socialSystematic exploration of predicted quaternary structures within pandemic-relevant viral proteomes
@joostsnijder.bsky.socialReposted by @danielhurdiss.bsky.socialFantastic evening at ARTIS cheering on Miguel for his @heinekenprizes.bsky.social Young Scientist award. Here with @danielhurdiss.bsky.social and @fmattiroli.bsky.social π
@bjgreber.bsky.socialReposted by @danielhurdiss.bsky.socialThose who had a careful look at the methods section of our work on the #cryoEM structure of the CDK11-cyclin L-SAP30BP complex will have noticed that we added a short peptide to our sample before freezing. If you wonder why...
@kaiyi94.bsky.socialReposted by @danielhurdiss.bsky.social1/7 Excited to share GuideFlip! We use guided discrete flow matching to co-design protein sequences and structures for flexible interactions, with experimental validation across three systems: Ξ±-synuclein, RBX1 and active-state GPCR nanobodies.
@turville.bsky.socialReposted by @danielhurdiss.bsky.socialSARS-CoV-2 phenotypic trajectory and the Omicron Paradox. Discussion of the following pre-print and the complex intertwined pathways that have dictated phenotypic outcomes for SARS-CoV-2. This can be otherwise termed the pandemic to endemic trajectory: www.biorxiv.org/content/10.6...
@cryoempapers.bsky.socialReposted by @danielhurdiss.bsky.socialIn-cell structures visualize human pre-ribosome assembly in the nucleolus pubmed.ncbi.nlm.nih.gov/42784657/ #cryoEM
@rasmusjensen.bsky.socialReposted by @danielhurdiss.bsky.social
@instruct-eric.bsky.socialReposted by @danielhurdiss.bsky.socialDave's contribution to Instruct continues, in the audience there is one of the Instruct-ERIC interns Tino Hoeksma from @danielhurdiss.bsky.social lab visiting Dave's lab at the @ox.ac.uk also part of Instruct-UK. The call for internships is now open! instruct-eric.org/submit-call/...
@danielhurdiss.bsky.socialAlso available in Dutch:
@bobcoelingh.bsky.socialReposted by @danielhurdiss.bsky.socialAmazing tool to keep track of all your big datasets!! Great to see @simon-alkema.bsky.social is continuing his tomo journey
@danielhurdiss.bsky.socialFor anyone interested in a more accessible overview of our recent norovirus paper, Utrecht University has now published a news item about the work.
@utrechtvirology.bsky.socialReposted by @danielhurdiss.bsky.socialCheck out the latest influenza work from the group of @xdh.bsky.social! π¦
Katherine Marougka et al explore how changes in the HAβNAβreceptor balance may have helped the 2009 pandemic H1N1 virus cross the species barrier from swine to humans.
@danielhurdiss.bsky.socialCongrats!
@avbroeck.bsky.socialReposted by @danielhurdiss.bsky.socialVery happy to share the first paper from our lab, out now in Nature Communications!ππ₯³
Structural basis of step II Spliced Leader RNA trans-splicing in trypanosomatid parasites π§¬π¬
π www.nature.com/articles/s41...
@natcomms.nature.com @universitedeliege.bsky.social @rockefeller.edu #cryoEM #cryo-EM
@structurabio.bsky.socialReposted by @danielhurdiss.bsky.socialπ A classic #cryoEM particle curation conundrum: 2D or 3D classification?
"Decoy Classification" using Heterogeneous Refinement in #CryoSPARC curates particles directly in 3D, helping remove junk particles while preserving valuable views.
Read more in the CryoSPARC Blog πΒ bit.ly/3SXfwS0
