Had an amazing time at the first PRIME Symposium - fantastic to meet such a lovely community of scientists, industry reps and people with lived experience of ME/CFS. Gave me a lot to think about for how to continue pushing forward research. Thank you #Prime26 !

Rob Wust (Amsterdam) shows that #pwME and #pwLC (all with PEM) *perfectly* separate from healthy controls with respect to their muscle microvasculature radius. Lower lumen radius in ME/LC. Needs replication, but this muscle biopsy metric has high diagnostic potential.
#MEcfs #PRIME26 #LongCovid

Dr Katharine Cheston on the @actionforme.bsky.social 2025 Big Survey Results. 5,424 people, 85.1% female; 18.4% v/severe. She is "shocked and appalled" by the data: by people's experience living with #MEcfs. Headline results will be released later in 2026.
#pwME #PRIME26

@cgatist.bsky.social
@meassociation.org.uk
@actionforme.bsky.social
#prime26 #PRIMEsymposium #pwme #me/cfs #mecfs #MyalgicEncephalomyelitis #buildingcapacity

New results. Eleven associations! Focuses on EXD3 Val540Met. (NB: unpublished results that need replication.)
Genetic overlap with neuronal, immune, endocrine and sleep traits.
EXD3 missense variant in exonuclease catalytic cleft. Immune function?
#Prime26

The 2026 PRIME symposium kicks off with reflections from Kelly McLellan on the importance of Patient and Public Involvement in ME/CFS research. #Prime26 #pwME #mecfs