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Version devBuilt at: 2026-10-11 02:37:10 EDT

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@sigtrans-sttt.bsky.socialOct 8, 2026, 4:15 PM

#Piezo1 links mechanical cues to bone marrow stem-cell fate. Its activation suppresses the Ccl2–CCR2–NF-κB–Lcn2 inflammatory loop, limiting adipogenesis while promoting osteoblast differentiation and #boneformation. #Osteoporosis

#STTT #OpenAccess: doi.org/10.1038/s413...

Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop
@isev.orgOct 1, 2026, 8:40 AM

🆕New in #JEV🆕 Shear Stress-Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance #extracellularvesicles #exercise #piezo1 #shearstress isevjournals.onlinelibrary.wiley.com/doi/epdf/10....

@ijosjournal.bsky.socialSep 11, 2026, 6:56 AM

In mice, removing both #Piezo1 and #Piezo2 slowed the maturation of dentin-forming odontoblasts and reduced Wnt/β-catenin signaling. Adding #Wnt10a restored odontoblast development in cultured tooth germs, connecting mechanical sensing with #tooth development.👇
www.nature.com/articles/s41...

@granuccilab.bsky.socialSep 10, 2026, 6:36 AM

What if PRRs are not the first to sense #infection?

🚨Our new paper out in #NatureImmunology! @natimmunol.nature.com
Microbial adhesion acts an unrecognized danger signal, activating #Piezo1 → LTB4 and triggering #PRR independent early #neutrophil recruitment.
🔗 www.nature.com/articles/s41...

@isev.orgSep 8, 2026, 11:25 AM

🆕New in #JExBio🆕 Engineering Piezo1-Mediated Calcium Signalling for Enhanced Extracellular Vesicle Biogenesis and Cargo Loading #extracellularvesicles #bioluminescence #piezo1 #proteomics isevjournals.onlinelibrary.wiley.com/doi/epdf/10....