A study does not account for an important confounder, but the data may allow reanalysis.

Would you recommend major revision, rejection, or ask the editor for specialist input?

What would make the difference for you?

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2/4
Then ask why the data are missing.

Are the missing observations random, or are they linked to a particular group, outcome, or study condition? That difference can matter a lot.

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2/4
Put those major concerns first.

Smaller points about wording, formatting, or presentation can still be useful, but they should not crowd out issues that affect the study itself.

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#ReviewerTip: A manuscript can read beautifully and still have problems with methods, evidence, or interpretation.

Polish helps with readability, but it should not influence how strongly the research itself is judged.

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2/4
Start with design alignment.

Do both components contribute to the same research question in a clear way, or do they feel like separate studies?

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