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@tomkindlon.bsky.socialOct 4, 2026, 10:16 PM

New from France

Interesting long Covid research where all participants satisfy ME/CFS criteria

Evidence for transcriptomic changes impacting muscle contraction in patients with post-acute COVID-19 syndrome

www.sciencedirect.com/science/arti...

#LongCovid #MEcfs #PwME #CFS #postcovid #postcovid19

Post-acute COVID-19 syndrome (PACS) overlaps with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) but, due to frequent muscle pain and exertional intolerance, neuromuscular disorders are often suspected. We report the results of a comprehensive neuromuscular evaluation in 27 PACS patients (22F/5M; median age 41 ys). All patients developed chronic fatigue (>6 months), post-exertional malaise, and cognitive impairment, with muscle pain in 88% but no neuromuscular deficits at clinical examination. 18/27 patients were unable to work. All patients fulfilled established ME/CFS diagnostic criteria (CDC 1994, ICC 2011, Inst Medicine 2015, NICE 2021). Electrophysiological studies and CK levels were normal. Brain 18FDG-PET/MRI (14/27) showed posterior hypometabolism in 8/14. Muscle biopsy (7/27) showed moderate dysimmune changes in 2/7. Exploratory transcriptomic analyses performed in muscle biopsies from PACS patients and pre-COVID controls unveiled in PACS differentially expressed genes in the cytokine and autophagy pathways. Interestingly, other genes were also differentially expressed in pathways affecting actin, the cytoskeleton, and contraction. Indeed, we found upregulated genes involved in the troponin-tropomyosin complex, a key regulator of muscle contraction through calcium binding. We also found downregulated genes involved in the formation and stabilization of actin bundles at sarcomere Z discs and in mechanical signaling. These findings indicate that PACS patients with prominent muscular symptoms do not exhibit overt neuromuscular involvement on standard investigations but may show subtle myopathic or dysimmune changes and central metabolic alterations. At the transcriptomic level, the data show an impact on key pathways involved in contraction. The overlap with ME/CFS highlights the importance of careful differential diagnosis and suggests a complex pathophysiology beyond a basic muscle disease.
@emergeaustralia.bsky.socialOct 4, 2026, 9:00 PM

Shop #BettytheBattery plushies, T-shirts, socks and more, featuring artwork by Amanda Francey & Shiloh Moore.

Every purchase supports #EmergeAustralia’s work for people living with #mecfs & #longcovid 🎁 zurl.co/3YR9B

#ChristmasGifts

Emerge Australia Christmas merchandise graphic on a navy background with green starbursts. Text reads: “Gifts that give more. Christmas gifting by Emerge Australia. Shop the range.” Products shown include a CureME drink bottle, black tote bag, “Do Not Disturb – Recharge in Progress” eye mask and patterned socks.
@shawneee.bsky.socialOct 4, 2026, 8:36 PM

Might be of interest for anyone with ME/CFS. #ME/CFS #disability #longcovid #health

@s4me.infoOct 4, 2026, 8:33 PM

Our latest News in Brief summary has headlines and links to further reading about ME/CFS, Long Covid, and related news for the week of Sept. 28 - Oct 4:

s4me.info/threads/news...

#MEcfs #PwME #LongCovid #PwLC

@benking01.bsky.socialOct 4, 2026, 7:50 PM

6 hours since the gym and I've mostly been lying down.

In fact, of the past 24 hours, I've been resting (mostly lying down, otherwise sitting) for 20 hours.

Just under 3 hours of 'Light' movement.

61 minutes of 'Moderate' movement.

And 4 glorious minutes on a treadmill 😔

Life with #LongCovid

KiActiv movement graphs as described
@taniaspencer.bsky.socialOct 4, 2026, 7:41 PM

An odd opinion piece: especially in light of the fact that #COVID is not yet endemic (steady/predictable); surges at least 2x p.a.; there's 0 cure for #LongCOVID, vaccination slightly reduces the risk of which; & vaccine acquired immunity is short lived (so 2x yearly vaccination makes sense).

@johntopham.bsky.socialOct 4, 2026, 4:51 PM

Another study relevant to my #longcovid friends

Covid fatigue linked to reduced brain blood flow

www.sciencedirect.com/science/arti...

@airiredcat.bsky.socialOct 4, 2026, 4:42 PM

Interessante Studie zu #Darmgesundheit und #Parkinson, die mir gerade in die TL gespült wurde.

Mehr B-Vitamine könnten auch für #LongCovid #MECFS und #MCAS relevant sein und gibt's in der Drogerie. Probier ich gleich mal aus.

en.nagoya-u.ac.jp/news/article...

@waysidescribbles.bsky.socialOct 4, 2026, 4:28 PM

September round-up. This month’s scribbles from the wayside. 🧵

Any favourite?

#longcovid #ableism #satire

A black-and-white cartoon featuring title text that reads "September round-up @waysidescribbles". Below, a person stands gestures while saying: "PERSONALLY, I DON'T THINK SCRIBBLES ARE A REAL THING".
@anna-lyst.bsky.socialOct 4, 2026, 4:28 PM

./4
Bedenke: Jede(!) weitere Reinfektion, auch asymptomatisch, ist eine erneute Lotterie-Teilnahme für #LongCovid !🧐

Mit jeder #Covid19 Reinfektion kumuliert das Risiko. Das bedeutet, mit jeder Infektion wird das Risiko größer (LongCovid, teils lebenslange Beeinträchtigungen)! Wird so hingenommen?🤬

Viele Studien zeigen längst: Mit jeder SARS-CoV-2-Reinfektion kumuliert das Risiko. Das bedeutet, mit jeder Infektion wird das Risiko (auf LongCovid, teils lebenslange Beeinträchtigungen) größer!
Man spielt mit jeder neuen Covid Infektion jedes Mal Roulette (auf das zusätzliche, sich potenzierende Risiko LongCovid).

Am besten bleibt daher: Infektionsvermeidung!

Link zum Ausgangs-Beitrag von Ralf Wittenbrink über die 'Science'-Studie: https://bsky.app/profile/ralfwittenbrink.bsky.social/post/3l7ivtle74a2q

❤️lichen Dank @ralfwittenbrink.bsky.social 💐
@benking01.bsky.socialOct 4, 2026, 3:16 PM

My #LongCovid life...

Resting in an armchair with my legs crossed for as much time as I'm actually cooking (cauliflower soup) 🙏

Heartrate graph from Visible Health
@drelke.bsky.socialOct 4, 2026, 3:15 PM

Yes - we‘ve gone from only a tiny minority of HCPs having heard of the term PEM, to many more referencing it - but without really understanding what it is and what it means to live with PEM.

I don’t know what’s worse…

#LongCovid
#ME

@exceedhergrasp1.bsky.socialOct 4, 2026, 2:24 PM

In general, we need to think from the perspective of the respondent. Memorably, first question on one survey: Do you have #LongCOVID, #MECFS, "or" #POTS?

You could only choose one.

@hardknoxfirst.bsky.socialOct 4, 2026, 2:20 PM

"Brain Scans of 24 People With #LongCOVID Reveal Signs of Injury to Dopamine Neurons" (Science Alert) on SmartNews: l.smartnews.com/p-8CuTXPA4/P... #SmartNews

@hardknoxfirst.bsky.socialOct 4, 2026, 2:06 PM

"Study Finds Shared Cause of Chronic Fatigue" #MECFS #LongCOVID #PTSD #RA #MS on SmartNews: l.smartnews.com/p-8CuEE03C/B... #SmartNews

@lesserspottedh.bsky.socialOct 4, 2026, 1:51 PM

Very interesting, but it’s a pity only 24 patients were studied.
And isn‘t it ever so depressing that #LongCovid manifests in so many diverse symptoms.😢