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@tomkindlon.bsky.social Oct 9, 2026, 12:02 AM

From Ireland

Characterizing Host Inflammatory Bioprofiles in People With Postacute Sequelae SARS-CoV-2 Infection (PASC)

onlinelibrary.wiley.com/doi/10.1155/...

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#LongCovid #PASC #PwLC #postcovid #postcovid19

Characterizing Host Inflammatory Bioprofiles in People With Postacute Sequelae SARS-CoV-2 Infection (PASC) — Marmont et al
"six distinct inﬂammatory clusters were identified within people with PASC, three of which showed elevated biomarkers related to tissue damage and repair, coagulation, axonal injury, and antiviral immune responses and were associated with component 3 of the complement pathway."
Article | Thread

@tomkindlon.bsky.social Oct 8, 2026, 11:51 PM

From the US

Neurocognitive Indices of Long COVID: Dysregulated Engagement of Inhibitory Control and Oscillatory Slowing

www.mdpi.com/2673-4087/7/...

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#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Neurocognitive Indices of Long COVID: Dysregulated Engagement of Inhibitory Control and Oscillatory Slowing — White et al
"Taken together, these findings clearly indicate that even mild PASC is associated with significant alterations in cell signaling, characterized by oscillatory slowing."
Article | Thread

@tomkindlon.bsky.social Oct 4, 2026, 10:16 PM

New from France

Interesting long Covid research where all participants satisfy ME/CFS criteria

Evidence for transcriptomic changes impacting muscle contraction in patients with post-acute COVID-19 syndrome

www.sciencedirect.com/science/arti...

#LongCovid #MEcfs #PwME #CFS #postcovid #postcovid19

Post-acute COVID-19 syndrome (PACS) overlaps with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) but, due to frequent muscle pain and exertional intolerance, neuromuscular disorders are often suspected. We report the results of a comprehensive neuromuscular evaluation in 27 PACS patients (22F/5M; median age 41 ys). All patients developed chronic fatigue (>6 months), post-exertional malaise, and cognitive impairment, with muscle pain in 88% but no neuromuscular deficits at clinical examination. 18/27 patients were unable to work. All patients fulfilled established ME/CFS diagnostic criteria (CDC 1994, ICC 2011, Inst Medicine 2015, NICE 2021). Electrophysiological studies and CK levels were normal. Brain 18FDG-PET/MRI (14/27) showed posterior hypometabolism in 8/14. Muscle biopsy (7/27) showed moderate dysimmune changes in 2/7. Exploratory transcriptomic analyses performed in muscle biopsies from PACS patients and pre-COVID controls unveiled in PACS differentially expressed genes in the cytokine and autophagy pathways. Interestingly, other genes were also differentially expressed in pathways affecting actin, the cytoskeleton, and contraction. Indeed, we found upregulated genes involved in the troponin-tropomyosin complex, a key regulator of muscle contraction through calcium binding. We also found downregulated genes involved in the formation and stabilization of actin bundles at sarcomere Z discs and in mechanical signaling. These findings indicate that PACS patients with prominent muscular symptoms do not exhibit overt neuromuscular involvement on standard investigations but may show subtle myopathic or dysimmune changes and central metabolic alterations. At the transcriptomic level, the data show an impact on key pathways involved in contraction. The overlap with ME/CFS highlights the importance of careful differential diagnosis and suggests a complex pathophysiology beyond a basic muscle disease.

@tomkindlon.bsky.social Oct 2, 2026, 12:41 AM

From Sweden

Booster dose of COVID-19 vaccine and its effectiveness against post COVID-19 condition in individuals with pre-existing immunity

www.thelancet.com/journals/ecl...

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#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome

Booster dose of COVID-19 vaccine and its effectiveness against post COVID-19 condition in individuals with pre-existing immunity: a sequential propensity score-matched cohort study — Morris et al
"we demonstrate that receiving a fourth dose of COVID-19 vaccine is associated with a decreased risk of being diagnosed with post COVID-19 condition during the first 6 months after vaccination, although the incidence rate difference was small."
Article | Thread

@tomkindlon.bsky.social Oct 1, 2026, 12:34 AM

From the UK

An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial

dx.doi.org/10.1093/oxfi...

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#LongCovid #PASC #PwLC #postcovid #postcovid19

An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial — Faghy et al
"The mean (SD) distance achieved in the 6MWT was 408 (113) metres at baseline compared to 468 (109) metres post-intervention" "whilst improvements were observed in health-related quality of life, the mean change in EQ-5D-5L index score (0.06) did not exceed the published MCID of 0.11" "Improvements could reflect natural fluctuation in symptom burden, behavioural modification associated with trial participation, or expectation effects."
Article | Thread

@tomkindlon.bsky.social Sep 30, 2026, 12:30 AM

The Post-Acute Effects of COVID-19 Are Not Associated with Robust Long-Term Regional or Global Brain Volumetric Changes: A Bayesian Meta-Analytic Evidence

www.sciencedirect.com/science/arti...

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#LongCovid #NeuroPASC #COVIDBrain #PASC #postcovid #postcovid19

The Post-Acute Effects of COVID-19 Are Not Associated with Robust Long-Term Regional or Global Brain Volumetric Changes: A Bayesian Meta-Analytic Evidence — Costa et al
"our focused examination of both global and regional volumetric changes not only provides deeper spatial insights compared to previous primary studies but also addresses the substantial methodological heterogeneity" "Results highlighted that while either global or local alteration was reported by independent studies, this evidence remains unsupported when they are considered on a meta-analytic level."

@tomkindlon.bsky.social Sep 25, 2026, 12:34 AM

From the UK

Bidirectional Associations Between Autonomic Function, Sleep Quality, & Daily Fatigue & Energy Symptoms in Long COVID: Longitudinal Digital Health Study

cardio.jmir.org/2026/1/e99630

s4me.info/threads/bidi...

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#LongCovid #PASC #PwLC #postcovid19

Bidirectional Associations Between Autonomic Function, Sleep Quality, and Daily Fatigue and Energy Symptoms in Long COVID: Longitudinal Digital Health Study — Aboagye et al.
"sleep duration and REM sleep showed significant within-person (day-to-day) associations with next-day fatigue, and sleep efficiency showed a counterintuitive negative association with next-day energy"
Article | Thread

@tomkindlon.bsky.social Sep 23, 2026, 12:32 AM

From Germany

Association of mRNA SARS-CoV-2 vaccination with fatigue and functional recovery in patients with post-acute sequelae of COVID-19 (PASC)

www.tandfonline.com/doi/abs/10.1...

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#LongCovid #PASC #PwLC #postcovid #postcovid19

Association of mRNA SARS-CoV-2 vaccination with fatigue and functional recovery in patients with post-acute sequelae of COVID-19 (PASC) — Pries et al
"Adults with […] PASC and at least two visits 3 to 6 months apart […] were eligible." "The exposure of interest was receipt of an additional SARS-CoV-2 vaccination" "we did not detect a statistically significant worsening of fatigue or exercise capacity" "Both vaccinated and non-vaccinated participants showed gradual improvement over time."
Article | Thread

@tomkindlon.bsky.social Sep 22, 2026, 12:40 AM

From Sweden

Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition

link.springer.com/article/10.1...

s4me.info/threads/long...

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#LongCovid #COVIDLung #PASC #PwLC #postcovid #postcovid19

$Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition — Nikesjö et al "Distinct DNAm patterns were observed across pulmonary immune cell fractions, with longitudinal changes primarily detected in neutrophil- and macrophage-enriched populations, while alterations were not evident in PBMCs." "This divergence between lung and blood suggests tissue-specific epigenetic remodeling following SARS-CoV-2 infection and underscores the limitations of relying solely on peripheral blood to capture disease-relevant molecular changes in PCC." Article | Thread$

@tomkindlon.bsky.social Sep 21, 2026, 4:49 PM

Press release from Karolinska Institutet (a medical university)

"Brain blood flow linked to fatigue after COVID-19"
news.ki.se/brain-blood-...

Paper:
www.sciencedirect.com/science/arti...

#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Published: 15-09-2026 11:56 | Updated: 16-09-2026 13:37
Brain blood flow linked to fatigue after COVID-19
An AI-generated image depicting a woman holding her head in pain, surrounded by a crowd of people in rush-hour traffic.
The image was generated using an AI tool. Photo: Sonia Miri Hedberg,AI-genererad bild
People with post-COVID-19 condition reported higher levels of fatigue and showed slower reaction times than healthy individuals. A new study from Karolinska Institutet, published in NeuroImage: Reports, also found lower blood flow in several parts of the brain, which may be linked to the cognitive difficulties experienced by many people after COVID-19.

@tomkindlon.bsky.social Sep 21, 2026, 12:23 AM

From Sweden

Cognitive fatigue is related to reduced cerebral perfusion & sustained attention in patients with post COVID-19 condition: An fMRI study

www.sciencedirect.com/science/arti...

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#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Cognitive fatigue is related to reduced cerebral perfusion and sustained attention in patients with post COVID-19 condition: An fMRI study — Hedberg et al
"Perfusion analysis revealed reduced CBF, not only in several regions but also globally across the whole brain and correlated with overall reaction time as well as individual performance variability"
Article | Thread

@tomkindlon.bsky.social Sep 6, 2026, 9:23 PM

“For Many Americans, Covid Is Still a Chronic, Disabling Disease. These Scientists Are Working Tirelessly to Bring Them Relief” (Smithsonian magazine) by Mike Mariani

www.smithsonianmag.com/innovation/m...

Feature article on research into Long Covid.

#LongCovid #PASC #PostCovid #PostCovid19